Table 1 Clinical characteristics of study subjects.

From: Prolonged bedrest reduces plasma high-density lipoprotein levels linked to markedly suppressed cholesterol efflux capacity

 

Pre-bedrest baseline

Day 21 of bedrest

p-value

Bedrest group

N

11

11

 

Total cholesterol (mg/dL)

143.5 ± 20.0

122.0 ± 21.2

0.001

HDL-cholesterol (mg/dL)

36.8 ± 6.7

30.0 ± 6.8

0.001

LDL-cholesterol (mg/dL)

90.2 ± 15.9

79.6 ± 16.1

0.040

Total triglyceride (mg/dL)

82.6 ± 19.8

62.2 ± 13.3

0.014

Plasma apoA-I (mg/dL)

120.4 ± 13.7

97.8 ± 14.9

0.001

Plasma apoA-II (mg/dL)

36.0 ± 4.2

30.4 ± 2.8

0.002

Plasma SAA (mg/dL)

0.5 (0.2–0.6)

0.3 (0.2–0.9)

0.624

Bedrest plus RVE group

N

11

11

 

Total cholesterol (mg/dL)

161.1 ± 28.1

130.2 ± 24.4

0.002

HDL-cholesterol (mg/dL)

38.3 ± 6.7

29.8 ± 5.0

0.001

LDL-cholesterol (mg/dL)

102.9 ± 22.2

87.4 ± 20.0

0.029

Total triglyceride (mg/dL)

99.8 ± 34.7

65.1 ± 16.8

0.002

Plasma apoA-I (mg/dL)

127.3 ± 16.6

97.3 ± 9.5

0.001

Plasma apoA-II (mg/dL)

39.1 ± 3.2

30.6 ± 3.1

0.001

Plasma SAA (mg/dL)

0.8 (0.5–1.0)

0.8 (0.5–1.0)

0.966

  1. HDL-cholesterol, low-density lipoprotein cholesterol, total cholesterol, triglycerides, apoA-I, apoA-II and SAA were evaluated in plasma for the bedrest (n = 11) and the bedrest plus resistive vibration exersise (n = 11) groups. Data are presented as mean ± SD (normally distributed data), or as median with interquartile range (not normally distributed data). Differences between pre-bedrest baseline and day 21 of bedrest were analyzed either with the paired t test, two-tailed (for normally distributed data), or with the Wilcoxon matched-pairs signed rank test, two-tailed (for not normally distributed data). Significance level for the analyses was set to α = 0.05 and differences are indicated with the corresponding p-value.
  2. apoA-I apolipoprotein A-I, apoA-II apolipoprotein A-II, HDL high-density lipoprotein, LDL low-density lipoprotein, N number of subjects, RVE resistive vibration exercise, SAA serum amyloid A.