Fig. 4: AIBP expression in mouse CNV, non-lesion, and control (non-laser) retinal areas. | Communications Biology

Fig. 4: AIBP expression in mouse CNV, non-lesion, and control (non-laser) retinal areas.

From: Combination of apolipoprotein-A-I/apolipoprotein-A-I binding protein and anti-VEGF treatment overcomes anti-VEGF resistance in choroidal neovascularization in mice

Fig. 4

a, b, c AIBP mRNA (in red) detected by RNAscope counter stained by hematoxylin II in CNV, non-lesion, and non-laser retinal areas, repectively. The magnified images on the top show AIBP in RPE (orange arrowheads) and CNV membranes (orange arrows). Asterisk (*) indicates CNV membranes. Scale, 20 µm in magnified images and 40 µm in others. d, e, f Quantification of AIBP mRNA in the Cho-RPE, photoreceptors, and inner retina, respectively. N = 4 retinas for CNV (including CNV and non-lesion areas) and non-laser control. Data represent mean ± SEM. NS, p > 0.05. Statistical analysis was performed by one-way ANOVA with Tukey post hoc analysis. Cho choroid, ROS rod outer segment, RIS rod inner segment, ONL outer nuclear layer, OPL outer plexiform layer, INL inner nuclear layer, IPL inner plexiform layer, GCL ganglion cell layer.

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