Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

IRON HOMEOSTASIS

Radical sensing keeps noxious iron at bay

Nature Metabolism volume 1, pages 501–502 (2019)Cite this article

Subjects

Living organisms face the dual challenge of acquiring enough iron to perform biological functions while preventing toxic iron accretion. A study now shows that sensing of iron-catalysed free radicals by a druggable gene-regulatory pathway helps the body avoid iron poisoning.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: NRF2 links iron-induced oxidative stress to hepcidin.

References

  1. Camaschella, C. Blood 133, 30–39 (2019).

    Article  CAS  Google Scholar 

  2. Brissot, P. et al. Nat. Rev. Dis. Primers 4, 18016 (2018).

    Article  Google Scholar 

  3. Muckenthaler, M. U., Rivella, S., Hentze, M. W. & Galy, B. Cell 168, 344–361 (2017).

    Article  CAS  Google Scholar 

  4. Silvestri, L., Nai, A., Dulja, A. & Pagani, A. Vitam. Horm. 110, 71–99 (2019).

    Article  Google Scholar 

  5. Lim, P. J. et al. Nat. Metab. https://doi.org/10.1038/s42255-019-0063-6 (2019).

    Article  Google Scholar 

  6. Cuadrado, A. et al. Nat. Rev. Drug Discov. 18, 295–317 (2019).

    Article  CAS  Google Scholar 

  7. Daher, R. et al. Gastroenterology 150, 672–683.e4 (2016).

    Article  CAS  Google Scholar 

  8. Crielaard, B. J., Lammers, T. & Rivella, S. Nat. Rev. Drug Discov. 16, 400–423 (2017).

    Article  CAS  Google Scholar 

  9. Nai, A. et al. Blood 127, 2327–2336 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatric Hematology, Oncology and Immunology, University of Heidelberg, Heidelberg, Germany

    Sandro Altamura

  2. Division of Virus-associated Carcinogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Bruno Galy

Authors
  1. Sandro Altamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bruno Galy
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Bruno Galy.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Altamura, S., Galy, B. Radical sensing keeps noxious iron at bay. Nat Metab 1, 501–502 (2019). https://doi.org/10.1038/s42255-019-0070-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s42255-019-0070-7

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing