Exhaustion of pancreatic beta cells in the face of prolonged insulin resistance results in the development of type II diabetes. Ansarullah et al. now describe an inhibitor of beta-cell insulin signalling that, on removal, increases beta-cell mass and improves beta-cell function, with potential as a new way to address beta-cell failure.
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Burchfield, J.G., James, D.E. A co-receptor that represses beta-cell insulin action. Nat Metab 3, 126–127 (2021). https://doi.org/10.1038/s42255-021-00352-4
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DOI: https://doi.org/10.1038/s42255-021-00352-4