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Obesity

Illuminating the ‘healthy obese’ phenotype

Nature Metabolism volume 5, pages 193–194 (2023)Cite this article

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Some individuals with obesity have a healthy metabolic profile and are not at increased risk for diabetes or cardiovascular disease. The mechanisms behind this phenomenon are poorly understood, but recent work now characterizes the biological underpinnings of the metabolically healthy obese phenotype.

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Fig. 1: Two individuals with the same BMI can have very different risks for T2D.

References

  1. NCD Risk Factor Collaboration (NCD-RisC). Lancet 390, 2627–2642 (2017)..

  2. Loos, R. J. F. & Yeo, G. S. H. Nat. Rev. Genet. 23, 120–133 (2022).

    Article  CAS  PubMed  Google Scholar 

  3. Coral, D. et al. Nat. Metab. https://doi.org/10.1038/s42255-022-00731-5 (2023).

    Article  PubMed  Google Scholar 

  4. Yengo, L. et al. Hum. Mol. Genet. 27, 3641–3649 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Mahajan, A. et al. Nat. Genet. 50, 1505–1513 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Fox, C. S. et al. Circulation 116, 39–48 (2007).

    Article  PubMed  Google Scholar 

  7. Rosen, E. D. & Spiegelman, B. M. Nature 444, 847–853 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Karlsson, T. et al. Nat. Med. 25, 1390–1395 (2019).

    Article  CAS  PubMed  Google Scholar 

  9. Shungin, D. et al. Nature 518, 187–196 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Rask-Andersen, M., Karlsson, T., Ek, W. E. & Johansson, Å. Nat. Commun. 10, 339 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Yengo, L. et al. Nature 610, 704–712 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Sun, B. B. et al. Preprint at bioRxiv https://doi.org/10.1101/2022.06.17.496443 (2022).

  13. Eraslan, G. et al. Science 376, eabl4290 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

A.J. is supported by the Swedish Research Council (2019-01497), the Swedish Heart-Lung foundation (20200687) and the Swedish Cancer Society (22 2222 Pj). M.R.-A. is supported by the Marcus Borgström and Åke Wiberg Foundations.

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Authors and Affiliations

  1. Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden

    Mathias Rask-Andersen & Åsa Johansson

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  1. Mathias Rask-Andersen
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  2. Åsa Johansson
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Correspondence to Åsa Johansson.

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Rask-Andersen, M., Johansson, Å. Illuminating the ‘healthy obese’ phenotype. Nat Metab 5, 193–194 (2023). https://doi.org/10.1038/s42255-022-00733-3

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