In vitro-transcribed RNA is a promising emerging class of therapeutic, but the poor specificity of cargo RNAs so far has limited their application in cancer immunotherapy. A new study reports the delivery of a synthetic circular RNA with inline cis-acting translational elements — encoding an engineered, mitochondrion-specific oncolytic protein — that shows both therapeutic and prophylactic potential against adenocarcinoma.
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Change history
14 February 2024
In the version of the article initially published, several instances of "translated" and "translational" originally appeared as "transcribed" and "transcriptional". This has now been corrected in the HTML and PDF versions of the article.
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Hamilton, A.G., Mitchell, M.J. An oncolytic circular RNA therapy. Nat Cancer 5, 5–7 (2024). https://doi.org/10.1038/s43018-023-00627-7
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DOI: https://doi.org/10.1038/s43018-023-00627-7