Extended Data Fig. 7: Schematic model of the distinct types of stem cell divisions determine HF homeostasis and aging. | Nature Aging

Extended Data Fig. 7: Schematic model of the distinct types of stem cell divisions determine HF homeostasis and aging.

From: Distinct types of stem cell divisions determine organ regeneration and aging in hair follicles

Extended Data Fig. 7

Young HFSCs undergo symmetric cell divisions (SCDs) and asymmetric cell divisions (ACDs) to generate new bulge cells for their self-renewal and expansion. Whereas aged HFSCs provoke hemidesmosomal instability including COL17A1 and undergo stress response (SR) type ACDs to induce epidermal differentiation that triggers their delamination, thereby causing stepwise miniaturization of HFs and hair thinning and loss.

Back to article page