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NEURODEGENERATION

Gut mitochondrial defects drive neurodegeneration

Nature Aging volume 2, pages 277–279 (2022)Cite this article

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Neurodegenerative diseases, including Parkinson’s disease, are linked to the accumulation of defective mitochondria in the brain and to microbial dysbiosis in the gut. However, the interplay between these factors is incompletely understood. Fedele et al. reveal how gut mitochondrial dysfunction activates intestinal inflammation to drive neurodegeneration in a Parkinson’s disease model.

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Fig. 1: Activation of the immune response in intestinal cells, due to mitochondrial dysfunction, is required for neurotoxicity in a Drosophila model of PD.

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Acknowledgements

D.W.W. is supported by NIH grants R01AG037514 and RF1AG049157.

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Authors and Affiliations

  1. Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA

    Ricardo Aparicio, Edward T. Schmid & David W. Walker

  2. Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA

    David W. Walker

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  1. Ricardo Aparicio
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  2. Edward T. Schmid
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  3. David W. Walker
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Correspondence to Ricardo Aparicio or David W. Walker.

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Aparicio, R., Schmid, E.T. & Walker, D.W. Gut mitochondrial defects drive neurodegeneration. Nat Aging 2, 277–279 (2022). https://doi.org/10.1038/s43587-022-00206-y

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