After three decades of work, hypothesis-generating genomic approaches have led to the identification of several intracranial aneurysm risk loci and Mendelian mutations, involving several unexpected genes. These findings opened the door for exciting opportunities, unraveling the genomic architecture of brain aneurysms. The field is now ripe to face the next set of surprises in this long journey.
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Acknowledgements
We thank K. Yasuno (Department of Neurosurgery, Yale University), K. Mishra-Gorur (Department of Neurosurgery, Yale University) and Mark Youngblood (Department of Neurosurgery, Northwestern University) for their input.
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Barak, T., Günel, M. The quest to unravel the complex genomics of intracranial aneurysms. Nat Cardiovasc Res 1, 281–282 (2022). https://doi.org/10.1038/s44161-022-00051-7
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DOI: https://doi.org/10.1038/s44161-022-00051-7