Figure 6
Niacin deficiency promotes PGE2 production via ROS formation.
(A) The level of mRNA for Ptges in keratinocytes was measured. Data are presented as means ± SEM. *, P < 0.05. (B) Keratinocyte production of PGE2 in culture supernatants were quantified. Data are presented as means ± SEM. *, P < 0.05. (C) Keratinocytes were collected and ROS production was measured (represented as relative fluorescence units, RFU). Data are presented as means ± SEM. *, P < 0.05. (D) UVB-irradiated skin with or without 6-AN treatment were administered with indomethacin (Indo) and then collected at day 7 after UVB exposure for measurement of ROS production. Data are presented as means ± SEM. *, P < 0.05.
