Table 1 Genotype and minor allele frequencies of 9 SNPs in 6 genes in morning, intermediate and evening types

				M (N = 245)			I (N = 594)			E (N = 86)			M	I	E
Gene	SNP	Allele (A/a)	Variation (amino acid)	AA	Aa	aa	AA	Aa	aa	AA	Aa	aa	MAF			P (χ2)
CLOCK	rs1801260	T/C		0.714	0.269	0.016	0.714	0.263	0.024	0.64	0.302	0.058	0.151	0.155	0.209	0.162
NPAS2	rs2305160	G/A	A/T	0.629	0.322	0.049	0.677	0.288	0.035	0.628	0.291	0.081	0.21	0.179	0.227	0.163
PER1	rs2585405	C/G	P/A	0.339	0.502	0.159	0.347	0.461	0.192	0.349	0.512	0.14	0.41	0.423	0.395	0.75
PER2	rs2304672	C/G		0.873	0.127	0	0.904	0.094	0.002	0.872	0.128	0	0.063	0.049	0.064	0.411
	rs934945	G/A	G/E	0.478	0.396	0.127	0.476	0.441	0.082	0.465	0.43	0.105	0.324	0.303	0.32	0.662
PER3	rs228697	C/G	P/A	0.898	0.102	0	0.833	0.163	0.003	0.791	0.186	0.023	0.051	0.085	0.116	0.01*
	rs2640909	T/C	M/T	0.812	0.184	0.004	0.771	0.214	0.015	0.767	0.198	0.035	0.096	0.122	0.134	0.238
TIM	rs774047	A/G	Q/R	0.363	0.449	0.188	0.347	0.463	0.19	0.372	0.43	0.198	0.412	0.422	0.413	0.927
	rs2291739	C/T	P/L	0.347	0.445	0.208	0.301	0.49	0.209	0.326	0.442	0.233	0.431	0.454	0.453	0.679

A, major allele; a, minor allele; M, morning type; I, intermediate type; E, evening type; N, number; P, P value for the difference in MAF among M, I and E;
*, P < 0.05.

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