Table 3 Univariate and multivariate analysis of OS in HCC patients.

Variable	Number	Univariate analysis	Multivariate nalysis
Variable	Number	P value	HR (95% CI)	P value
Histology:
Tumor HNF-1B expression
Low vs High	134 vs 49	0.001*	1.637(1.093,2.450)	0.017*
Tumor K19 expression
Low vs High	89 vs 94	0.013*		NS
Tumor K7 expression
Low vs High	84 vs 99	<0.001*	1.799(1.220,2.654)	0.003*
Tumor EpCAM expression
Low vs High	95 vs 88	0.321		NA
Tumor OV6 expression
Low vs High	88 vs 95	0.509		NA
Non-tumor HNF-1B expression
Low vs High	134 vs 49	0.026*		NS
Clinical characteristics
Age(yr)
<50 vs ≥50	96 vs 87	0.129		NA
Gender
Male vs Female	162 vs 21	0.924		NA
Tumor size
<5 cm vs ≥5 cm	89 vs 94	0.012*	1.461(1.012,2.108)	0.043*
Tumor number
Single vs Multiple	159 vs 24	0.071	1.708(1.004,2.904)	0.048*
Cirrhosis
No vs Yes	125 vs 58	0.308		NA
TNM stage
I/II vs III	166 vs 17	0.015*		NS
HbsAg
Negative vs Positive	11 vs 172	0.606		NA
Serum AFP
<400 vs ≥400	116 vs 67	0.428		NA
Histological grade
Well/moderate vs poorly	133 vs 50	0.592		NA
Lymphovascular invasion
Negative vs Positive	66 vs 117	0.008*	1.633(1.101,2.423)	0.015*

NA, not adopted; NS, not significant; HR, hazard ratio; Factors with p < 0.1 in univariate analysis were adopted for further multivariate analysis. *P < 0.05 was considered statistically significant.

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