Table 3 The information of the metabolites of GZFL in human plasma.

From: Integrated identification, qualification and quantification strategy for pharmacokinetic profile study of Guizhi Fuling capsule in healthy volunteers

Metabolitecode

Parent ionsm/z

tR (min)

Formula

Product Ions m/z

Prototype

M1

151.0402

7.49

C8H8O3

65.0386, 92.0259, 136.1032, 151.0402

PA

M2

179.0714

9.27

C10H12O3

92.0267, 136.0158, 179.0714

PA

M3

181.0514

5.74

C9H10O4

135.0452, 163.0402, 181.0514

PA

M4

195.0665

8.23

C10H12O4

93.0326, 119.0494, 121.0316, 135.0456, 151.0755, 195.0665

PA

M5

230.9956

7.16

C8H8O6S

230.99, 151.04, 135.04, 109.03

PA

M6

245.0489

12.71

C9H10O6S

165.0921, 245.0489

PA

M7

261.0061

12.64

C9H10O7S

261.01, 181.05, 165.03, 135.03, 122.03

PA

M8

295.0973

9.18

C13H16N2O6

103.0545, 147.0457, 251.0968, 295.0973

PA

M9

327.0722

7.49

C14H16O9

85.0291, 113.0240, 151.0398, 175.0243, 327.0722

PA

M10

341.0879

7.72

C15H18O9

113.0256, 150.0323, 165.0555, 275.0433, 341.0903

PA

M11

357.0828

7.69

C15H18O10

59.0134, 113.0240, 166.0272, 175.0247, 181.0505, 357.0828

PA

M12

470.0044

6.26

C19H25N3O9S

75.0676, 99.0648, 113.0767, 161.0828, 470.0044

PA

M13

591.1805

6.73

C26H32N4O12

145.1044, 151.0808, 175.0652, 263.0945, 327.0282, 591.1805

PA

M14

655.1522

7.49

C28H33O18

113.0240, 151.0399, 175.0245, 327.0718, 413.2715, 655.1522

PA

M15

715.1705

7.1

C30H36O20

113.0765, 175.0561, 181.0803, 263.0438, 357.0217, 715.1705

PA

M16

135.0438

7.68

C8H8O2

135.04, 121.03, 77.04

PAE

M17

178.0512

6.69

C9H12NO3

178.05, 121.03, 77.04

PAE

M18

495.1632

7.11

C23H28O12

495.16, 479.16, 327.11, 165.05, 121.03, 77.04

PAE

M19

264.0722

4.11

C13H15NO5

264.08, 132.05, 116.06, 107.06

AMY

M20

308.0781

7.39

C14H15NO7

308.08, 132.05, 116.06, 107.06

AMY

M21

147.0737

12.41

C9H9NO

355.12, 341.12, 179.06

AMY

M22

125.0250

6.7

C6H6O3

79.0198, 124.0216, 125.0250

GA

M23

151.0427

7.70

C8H8O3

151.04, 107.05, 93.04, 79.02, 55.02

GA

M24

183.0304

5.10

C8H8O5

123.0132, 124.0204, 168.0153,183.0304

GA

M25

204.9810

6.65

C6H6O6S

79.9579, 125.0209, 204.9810

GA

M26

218.9977

7.02

C7H8O6S

79.9580, 124.0209, 139.0461,218.9977

GA

M27

262.9870

12.34

C8H8O8S

124.0213, 168.0155, 183.0405,262.9870

GA

M28

345.0463

2.55

C13H14O11

125.0293, 169.0234, 345.0463

GA

M29

275.1039

7.87

C14H16N2O4

91.0531, 109.0399, 112.0368, 127.0506, 147.0472, 275.1039

CA

M30

163.0405

5.74

C9H11O2

117.0560, 135.0454, 163.0405

CA

M31

168.0061

5.20

Unknown

124.0659, 168.0061

Unknown

M32

308.0767

6.72

Unknown

132.0405, 308.0767

Unknown

M33

340.1034

7.27

Unknown

None

Unknown

M34

329.1148

8.74

Unknown

171.1016, 211.1322, 229.1428, 329.1148

Unknown

M35

337.0624

6.27

Unknown

337.06, 161.06

Unknown

M36

771.3673

7.75

Unknown

771.36, 357.02

Unknown

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