Table 2 Pathway enrichment analysis in metabolome profiles of the maize samples.

From: An integrated multi-omics analysis of the NK603 Roundup-tolerant GM maize reveals metabolism disturbances caused by the transformation process

 

n/N

ES

p-value

Iso vs NK603 pathways

 Amines and polyamines

3/4

2.6

0.0370

 Nicotinate and nicotinamide metabolism

3/4

2.6

0.0370

 Fatty acid, Dicarboxylate

4/8

1.7

0.0797

 Aspartate family (OAA derived)

10/27

1.3

0.0908

 TCA cycle

3/6

1.7

0.1300

 Dipeptide

1/17

0.2

0.1359

 Free fatty acid

7/19

1.3

0.1557

 Branched Chain Amino Acids (pyruvate derived)

5/13

1.3

0.1780

 Phenylpropanoids

3/7

1.5

0.1914

 Photorespiration

2/4

1.7

0.2192

Iso vs NK603 + R pathways

 Amino sugar and nucleotide sugar

7/8

2.3

0.0007

 Serine family (phosphoglycerate derived)

7/10

1.8

0.0062

 Dipeptide

10/17

1.5

0.0096

 TCA cycle

4/6

1.7

0.0532

 Branched Chain Amino Acids (pyruvate derived)

7/13

1.4

0.0536

 Aspartate family (OAA derived)

12/27

1.2

0.0730

 Benzenoids

2/2

2.6

0.0769

 Phenylpropanoids

4/7

1.5

0.0978

 Glycolysis

3/5

1.6

0.1342

 Inositol metabolism

2/3

1.7

0.1885

NK603 vs NK603 + R pathways

 Phenylpropanoids

3/7

4.3

0.0180

 Amino sugar and nucleotide sugar

3/8

3.8

0.0271

 Fatty acid conjugate

1/1

10.1

0.0899

 Branched Chain Amino Acids (pyruvate derived)

3/13

2.3

0.1012

 Choline metabolism

1/2

5.1

0.1719

 gamma-glutamyl

2/10

2.0

0.2238

 Serine family (phosphoglycerate derived)

2/10

2.0

0.2238

 Fatty acid amide

1/3

3.4

0.2467

 Nicotinate and nicotinamide metabolism

1/4

2.5

0.3150

 Glycolysis

1/5

2.0

0.3773

  1. The 10 most altered pathways (ranked by p-values) are presented. The number of metabolites disturbed in each pathway (n) is compared to the total number of metabolites measured for the given pathway (N). Enrichment scores (ES) for each pathway are calculated as follow: ES = (number of significant metabolites in pathway/total number of detected metabolites in pathway)/(total number of significant metabolites/total number of detected metabolites). The p-values were calculated according to a one sided Fisher exact test.