Table 1 Parameters and boundary conditions input to the computational models.

R

31–5000 μm

From cell monolayers to 5 mm thick spheroids or tissue constructs.

24

c_o

0.2–0.03 moles/m³ or mM

Boundary conditions at the surface of the construct: implies media is well-mixed and continuously renewed at the surface.

25

4.8 × 10⁻¹⁷ moles/(cell.s)

Typical value for hepatocytes in-vitro.

20,24

ρ

5.14 × 10¹⁴ −5.14 × 10¹² cells/m³

From physiological cell density to typical in-vitro density (5 million cells/mL).

37

k_m

7.39 × 10⁻³ moles/m³

Typical value for hepatocytes.

24

D

3 × 10⁻⁹ m²/s

Diffusion constant in water at 37 °C.

24

Michaelis Menten consumption.