Figure 2
(A) Effect of PcTx1 bilateral microinjection (0.05 μg/rat/side, respectively, 15 min before the test) within the BLA of sham and MoAr rats on the time spent in social interactions. (B,C) Evaluation of locomotor activity in MoAr animals or sham rats injected or not with PcTx1 (B, distance travelled and C, velocity) during a 5 min session in the open field arena. (C–H) Effect of PcTx1 or mambalgin-1 bilateral microinjection (0.05 and 0.065 μg/rat/side, respectively, 15 min before the test) within the BLA of sham and MoAr rats on the the percentage of time spent in the open arms (C and F), the percentage of entries (D and G), and the distance travelled (E and H) in the elevated plus maze test after PcTx1 (C–E) or mambalgin-1 (F–H) injection. Tests were performed 14–16 days following monoarthritis induction. The movements of the animals in the EPM test were automatically recorded by a camera for 5 min and analyzed using Ethovision XT 8 (Noldus). n = 6–8 animals per group; One-way ANOVA followed by a Tuckey post hoc test. *p ≤ 0.05, **p ≤ 0.01 compared to sham saline group, °p ≤ 0.05, °°p ≤ 0.01 compared to MoAr saline group.
