Volume 40 Issue 6, June 2022

Editorial

Knock-in on CRISPR’s door

Interest is growing in genome-editing tools that can insert large chunks of DNA into the genome — and avoid the double-strand breaks associated with CRISPR–Cas9 genotoxicity.

Editorial 07 Jun 2022

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News

Unconventional γδ T cells ‘the new black’ in cancer therapy

A new era of cancer immunotherapy beckons as γδ T cell trials enter final stage.

Elie Dolgin
News 15 Jun 2022
Caribou’s first CRISPR CAR-T impresses

News in Brief 15 Jun 2022
Biotech news from around the world

News in Brief 15 Jun 2022
Topical herpesvirus gene therapy enters final lap

The first herpesvirus replacement gene therapy for epidermolysis bullosa, a blistering skin condition, approaches the clinic.

Cormac Sheridan
News 15 Jun 2022
FDA okays first cardiac myosin inhibitor

News in Brief 15 Jun 2022
AI’s plastic recycling

News in Brief 15 Jun 2022
Egg without the chicken

Lisa Melton
News 15 Jun 2022

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Bioentrepreneur

Data Page
- Biotech patenting 2021
  
  Brady Huggett
  Kathryn Paisner
  Bioentrepreneur Data Page 15 Jun 2022

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Correspondence

An open invitation to the Understudied Proteins Initiative

Georg Kustatscher
Tom Collins
Juri Rappsilber
Correspondence 09 May 2022
The GA4GH Phenopacket schema defines a computable representation of clinical data

Julius O. B. Jacobsen
Michael Baudis
Peter N. Robinson
Correspondence 15 Jun 2022

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Features

The Worldview national ranking of health biotech sectors

A survey of national R&D-driven health biotech sectors ranks Switzerland, Sweden and the United States as leading centers for R&D-driven biotech. John Hodgson and Deanna Schreiber-Gregory report.

John Hodgson
Deanna Schreiber-Gregory
Feature 01 Jun 2022
Patents
- Vascepa patents under legal scrutiny
  
  Even if Amarin prevails in its patent infringement lawsuit, its key patents on Vascepa are likely to be ruled invalid in ongoing litigation, opening the way for generic formulations.
  
  Gregory Curfman
  Justin Cole
  Patents 15 Jun 2022
- CRISPR technology
  
  Recent patents relating to CRISPR methods and compositions for gene editing and therapeutic use.
  
  Patents 15 Jun 2022

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News & Views

Antibiotic discovery with machine learning

Artificial intelligence finds candidate peptide antibiotics in the human gut microbiome.

Cesar de la Fuente-Nunez
News & Views 06 May 2022
Pathogenic or benign?

CRISPR base- and prime-editing pooled screens reveal the function of genetic variants at unprecedented resolution.

Peter P. Du
Katherine Liu
Gaelen T. Hess
News & Views 16 May 2022
Podcast
- Forum: Phillips-Cremins and Pombo
  
  Podcast 15 Jun 2022

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Research Briefings

Identification of antimicrobial peptides from the human gut microbiome using deep learning

Using a combination of metagenomic big data and deep learning tools, small proteins that inhibit pathogens — and could be further developed into novel antibiotics — are mined en masse. Such methods could greatly improve the throughput of drug discovery and translational usage of the microbiome.

Research Briefing 08 Mar 2022

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Research

Review Articles
- The clinical progress of mRNA vaccines and immunotherapies
  
  Anderson and colleagues discuss the progress and challenges of using mRNA for vaccines and immunotherapy.
  
  Ann J. Barbier
  Allen Yujie Jiang
  Daniel G. Anderson
  Review Article 09 May 2022
Brief Communications
- Cell types of origin of the cell-free transcriptome
  
  Cell types affected by various diseases are inferred from cell-free RNA.
  
  Sevahn K. Vorperian
  Mira N. Moufarrej
  Stephen R. Quake
  Brief Communication Open Access 07 Feb 2022
Articles
- Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants
  
  Improved base editing libraries enable high-throughput functional analysis of single-nucleotide variants in cancer.
  
  Francisco J. Sánchez-Rivera
  Bianca J. Diaz
  Lukas E. Dow
  Article 14 Feb 2022
- High-throughput functional evaluation of human cancer-associated mutations using base editors
  
  Cancer-associated variants of unknown significance are identified using base editing.
  
  Younggwang Kim
  Seungho Lee
  Hyongbum Henry Kim
  Article 11 Apr 2022
- Saturation variant interpretation using CRISPR prime editing
  
  Genetic variants of uncertain significance are characterized with a prime editing method.
  
  Steven Erwood
  Teija M. I. Bily
  Ronald D. Cohn
  Article 21 Feb 2022
- Massively parallel phenotyping of coding variants in cancer with Perturb-seq
  
  The functional impact of somatic mutations in cancer genes is determined by pooled Perturb-seq.
  
  Oana Ursu
  James T. Neal
  Jesse S. Boehm
  Article 20 Jan 2022
- A humanized mouse model of chronic COVID-19
  
  A mouse model of chronic COVID-19 facilitates the study of disease mechanisms and therapies.
  
  Esen Sefik
  Benjamin Israelow
  Richard A. Flavell
  Article 17 Dec 2021
- Identification of antimicrobial peptides from the human gut microbiome using deep learning
  
  Antimicrobial peptides are identified from metagenomics data using deep learning.
  
  Yue Ma
  Zhengyan Guo
  Jun Wang
  Article 03 Mar 2022
- Using deep learning to annotate the protein universe
  
  A deep learning model predicts protein functional annotations for unaligned amino acid sequences.
  
  Maxwell L. Bileschi
  David Belanger
  Lucy J. Colwell
  Article 21 Feb 2022
- Efficient in vitro and in vivo RNA editing via recruitment of endogenous ADARs using circular guide RNAs
  
  Circular guide RNAs boost the efficiency of RNA editing with endogenous ADARs.
  
  Dhruva Katrekar
  James Yen
  Prashant Mali
  Article 10 Feb 2022
- Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo
  
  Circular ADAR-recruiting RNAs improve RNA editing in vitro and in a mouse disease model.
  
  Zongyi Yi
  Liang Qu
  Wensheng Wei
  Article 10 Feb 2022
- Development of spirulina for the manufacture and oral delivery of protein therapeutics
  
  Spirulina is used to manufacture a therapeutic antibody against campylobacter.
  
  Benjamin W. Jester
  Hui Zhao
  James Roberts
  Article Open Access 21 Mar 2022
- Imaging of innate immunity activation in vivo with a redox-tuned PET reporter
  
  Inflammation is imaged in mice with a PET reporter of high-energy reactive oxygen and nitrogen species.
  
  Federica Pisaneschi
  Seth T. Gammon
  David Piwnica-Worms
  Article 21 Feb 2022

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Amendments & Corrections

Author Correction: Development of spirulina for the manufacture and oral delivery of protein therapeutics

Benjamin W. Jester
Hui Zhao
James Roberts
Author Correction Open Access 19 Apr 2022
Publisher Correction: Cell types of origin of the cell-free transcriptome

Sevahn K. Vorperian
Mira N. Moufarrej
Stephen R. Quake
Publisher Correction Open Access 28 Mar 2022

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Careers & Recruitment

Career Feature
- A virtual innovation bootcamp to remotely connect and empower students to solve COVID-19-related medical problems
  
  An intensive program supplements student education and collaboration while narrowing the disconnect between rising healthcare needs and trainees with the technical expertise to tackle pandemic-related challenges.
  
  Mario V. Russo
  Abhinav J. Appukutty
  Richard Xie
  Career Feature 15 Jun 2022
People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 15 Jun 2022

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Volume 40 Issue 6, June 2022

Algae-encoded biopharmaceuticals

Editorial

News

Bioentrepreneur

Data Page

Correspondence

Features

Patents

News & Views

Podcast

Research Briefings

Research

Review Articles

Brief Communications

Articles

Amendments & Corrections

Careers & Recruitment

Career Feature

People

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