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Showing 1–50 of 486 results

  • Regulatory T cells have pathological roles in driving fibrosis and insulin resistance in the setting of non-alcoholic steatohepatitis.

    • Yvonne Bordon
    Research Highlights
    Nature Reviews Immunology
    Volume: 24, P: 158

  • A preprint by Sugiura et al. looks at the role of one-carbon metabolism during T cell activation, with a focus on autoimmune disease, and identifies differences between T cell subsets.

    • Felix Clemens Richter
    • Alexander J. Clarke
    Research Highlights
    Nature Reviews Immunology
    Volume: 21, P: 206

    • Ioana Visan
    Research Highlights
    Nature Immunology
    Volume: 23, P: 988

  • Human memory CD4+ T cells primed in vivoby pathogens or vaccines are highly heterogeneous.

    • Elisabeth Kugelberg
    Research Highlights
    Nature Reviews Immunology
    Volume: 15, P: 3

    • Nicholas J. Bernard
    Research Highlights
    Nature Immunology
    Volume: 23, P: 2

    • Zoltan Fehervari
    Research Highlights
    Nature Immunology
    Volume: 20, P: 245

    • Laurie A. Dempsey
    Research Highlights
    Nature Immunology
    Volume: 19, P: 647

    • Stephanie Houston
    Research Highlights
    Nature Immunology
    Volume: 24, P: 1966

  • T follicular regulatory cells arise once infection resolves and IL-2 levels wane to prevent the outgrowth of self-reactive B cells.

    • Lucy Bird
    Research Highlights
    Nature Reviews Immunology
    Volume: 17, P: 662-663

    • Ioana Visan
    Research Highlights
    Nature Immunology
    Volume: 15, P: 1103

  • John O'Shea describes a 2000 paper by Roggeet al. that was the first to compare the transcriptomes of human TH1 cells and TH2 cells.

    • John O'Shea
    Research Highlights
    Nature Reviews Immunology
    Volume: 15, P: 668

    • Laurie A. Dempsey
    Research Highlights
    Nature Immunology
    Volume: 12, P: 931

    • Ioana Visan
    Research Highlights
    Nature Immunology
    Volume: 16, P: 906

  • Control of excessive T helper 2 cell-type immune responses is mediated by casein kinase 2 (CK2) in regulatory T cells.

    • Lucy Bird
    Research Highlights
    Nature Reviews Immunology
    Volume: 15, P: 134

  • Regulatory T cells suppress effector T cells by releasing exosomes that contain microRNAs.

    • Yvonne Bordon
    Research Highlights
    Nature Reviews Immunology
    Volume: 14, P: 581

  • Mother mice retain a small population of latent regulatory T cells from each pregnancy that remembers their offspring and protects against future pregnancy complications.

    • Lucy Bird
    Research Highlights
    Nature Reviews Immunology
    Volume: 23, P: 702

  • Visceral adipose tissue hosts at least two populations of mature FOXP3+ regulatory T cells, which together can preserve systemic metabolism and control inflammation.

    • Melanie Grusdat
    • Dirk Brenner
    News & Views
    Nature Immunology
    Volume: 25, P: 392-393

  • Intratumoral regulatory T (Treg) cells can suppress antitumor immunity. Unlike in splenic Treg cells, the H3K9me2 demethylase JMDJ1 seems to be induced, and is required for this function, in the tumor microenvironment, and targeting it with a small-molecule inhibitor can suppress tumor growth in mice.

    • Xuezheng Wang
    • Keji Zhao
    News & Views
    Nature Immunology
    Volume: 25, P: 390-391

  • T-bet+ regulatory T cells form a stable subset with specific suppressive activity towards T-bet+effector T cells.

    • Kirsty Minton
    Research Highlights
    Nature Reviews Immunology
    Volume: 17, P: 401

  • Ricardo Gazzinelli describes studies from the late 1980s and early 1990s that looked at the polarization of the recently described TH1 cell and TH2 cell subsets in the context of parasite infection.

    • Ricardo Gazzinelli
    Research Highlights
    Nature Reviews Immunology
    Volume: 19, P: 137

  • Chewing induces the accumulation of T helper 17 cells in the mouth.

    • Lucy Bird
    Research Highlights
    Nature Reviews Immunology
    Volume: 17, P: 81

  • NLRP3 functions independently of the inflammasome as a transcriptional regulator of T helper 2 cell differentiation.

    • Elisabeth Kugelberg
    Research Highlights
    Nature Reviews Immunology
    Volume: 15, P: 467

  • Steven Ziegler describes a 1986 study by Mossmannet al. that defined two subsets of T helper cells on the basis of their activities.

    • Steven F. Ziegler
    Research Highlights
    Nature Reviews Immunology
    Volume: 16, P: 403

  • TH17 but not TH1 cells are required for vaccine-induced protection from fungi.

    • Yvonne Bordon
    Research Highlights
    Nature Reviews Immunology
    Volume: 11, P: 74-75

  • A HIF1α-dependent metabolic switch influences the balance between TH17 and induced TRegcell differentiation.

    • Isabel Woodman
    Research Highlights
    Nature Reviews Immunology
    Volume: 11, P: 503

  • Developing TH1 cells pass through a transitional TH1–TFHcell stage.

    • Olive Leavy
    Research Highlights
    Nature Reviews Immunology
    Volume: 12, P: 75

  • A study in Immunity reports that a high-fat diet in mice leads to the loss of PPARγ+ Treg cells in the skin, which exacerbates psoriasis mediated by IL-17-producing γδ T cells.

    • Kirsty Minton
    Research Highlights
    Nature Reviews Immunology
    Volume: 23, P: 616

  • New research demonstrates that regulatory T cells in gut and joint tissues differ in their response to and ability to control TNF-mediated inflammation.

    • Robert Phillips
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 19, P: 461

    • Zoltan Fehervari
    Research Highlights
    Nature Immunology
    Volume: 23, P: 343

  • A preprint by Ramanan et al. examines the roles of accessory transcription factors in regulating subsets of colonic regulatory T cells, independently of the microbiota and T cell specificity.

    • Kyle Burrows
    • Arthur Mortha
    Research Highlights
    Nature Reviews Immunology
    Volume: 23, P: 544

    • Nicholas J. Bernard
    Research Highlights
    Nature Immunology
    Volume: 23, P: 1399

  • Commensal-specific T cells promote the regeneration of damaged sensory nerves in the skin, through an IL-17-dependent pathway.

    • Lucy Bird
    Research Highlights
    Nature Reviews Immunology
    Volume: 23, P: 138

    • Ioana Visan
    Research Highlights
    Nature Immunology
    Volume: 20, P: 945

    • Ioana Visan
    Research Highlights
    Nature Immunology
    Volume: 20, P: 776