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Showing 1–50 of 89 results

    • Yiyun Song
    Research Highlights
    Nature Chemical Biology
    Volume: 20, P: 3

    • Caitlin Deane
    Research Highlights
    Nature Chemical Biology
    Volume: 19, P: 536

  • Glycoproteomics is coming of age, thanks to advances in instrumentation, experimental methodologies and computational search algorithms.

    • Arunima Singh
    Comments & Opinion
    Nature Methods
    Volume: 18, P: 28

  • Challenges in the synthesis of heparan sulfate (HS) glycosaminoglycans have limited access to defined HS oligosaccharides bearing a diverse array of sulfation sequences. A concise, divergent synthetic approach now provides a library of 64 HS tetrasaccharides displaying a comprehensive set of sulfation sequences, offering insight into the elusive sulfation code of glycosaminoglycans.

    News & Views
    Nature Chemistry
    Volume: 15, P: 1062-1063

    • Laurie A. Dempsey
    Research Highlights
    Nature Immunology
    Volume: 23, P: 471

    • Terry L. Sheppard
    Research Highlights
    Nature Chemical Biology
    Volume: 17, P: 1211-1212

    • Philip Lössl
    Research Highlights
    Nature Chemical Biology
    Volume: 17, P: 839

    • Stacey-Lynn Paiva
    Research Highlights
    Nature Chemical Biology
    Volume: 19, P: 251

    • Ioana Visan
    Research Highlights
    Nature Immunology
    Volume: 20, P: 1558

    • Nicole Rusk
    Research Highlights
    Nature Methods
    Volume: 15, P: 481

  • Analyzing glycans is challenging because of their structural diversity and complexity and the lack of analytical techniques capable of resolving pools of similar glycan structures. A new method now enables imaging of single glycans, providing direct observation of individual glycans and glycoconjugates.

    • Martina Delbianco
    • Yu Ogawa
    News & Views
    Nature Chemical Biology
    Volume: 20, P: 11-12

    • Ioana Visan
    Research Highlights
    Nature Immunology
    Volume: 20, P: 1414

  • A chemoenzymatic strategy is introduced whereby a glycan backbone is assembled enzymatically to give a core oligosaccharide that is subjected to chemical manipulations to install terminal epitopes. A library of oligosaccharides containing the human natural killer-1 epitope was synthesized, enabling evaluation of the binding specificities of serum antibodies of patients with anti-myelin-associated glycoprotein neuropathy.

    News & Views
    Nature Synthesis
    Volume: 3, P: 15-16

    • Catherine Goodman
    Research Highlights
    Nature Chemical Biology
    Volume: 9, P: 291

    • Catherine Goodman
    Research Highlights
    Nature Chemical Biology
    Volume: 9, P: 754

    • Catherine Goodman
    Research Highlights
    Nature Chemical Biology
    Volume: 11, P: 829

    • Catherine Goodman
    Research Highlights
    Nature Chemical Biology
    Volume: 11, P: 2

    • Terry L. Sheppard
    Research Highlights
    Nature Chemical Biology
    Volume: 9, P: 665

    • Catherine Goodman
    Research Highlights
    Nature Chemical Biology
    Volume: 10, P: 795

    • Catherine Goodman
    Research Highlights
    Nature Chemical Biology
    Volume: 9, P: 8

  • A stepwise strategy of targeted synthesis enables researchers to reconstruct cellular glycomes in vitro.

    • Michael Eisenstein
    Research Highlights
    Nature Methods
    Volume: 10, P: 932

  • We developed OxoScan-MS, a mass spectrometric acquisition technology for high-throughput quantification of glycopeptides. When applied to plasma of patients with COVID-19, OxoScan-MS revealed differential glycosylation in disease-relevant proteins. This approach offers potential for large-scale applications, moving beyond traditional protein abundance measurements to explore glycosylated protein biomarkers.

    News & Views
    Nature Biomedical Engineering
    Volume: 8, P: 212-213

  • New biochemical and structural studies into the capsule biosynthesis pathway of Haemophilus influenzae serotype b (Hib) provide invaluable insights into a unique, basket-shaped multi-modular enzymatic machinery, allowing accelerated development of fermentation-free production methods for Hib glycoconjugate vaccine.

    • Helge C. Dorfmueller
    News & Views
    Nature Chemical Biology
    Volume: 19, P: 795-796

  • The COVID-19 pandemic has highlighted the importance of methodological advancements in basic biological research. We believe that method development will continue to propel both fundamental and applied studies on SARS-CoV-2 and other pathogens.

    Editorial
    Nature Methods
    Volume: 19, P: 371-372

  • They started their lab mid-COVID. The new principal investigator adventure is a roller-coaster ride with some unexpected surprises.

    • Vivien Marx
    News
    Nature Methods
    Volume: 20, P: 1268

  • High-mannose N-glycans are common post-translational modifications that occur on many proteins. The mechanism by which these high-mannose N-glycans are consumed by species of Bifidobacterium has now been characterized, which is important given their positive role in human gut microbiota and their abundance in breastfed infants.

    • Lucy I. Crouch
    News & Views
    Nature Chemical Biology
    Volume: 19, P: 131-132

  • The rising threat of antifungal resistance means that alternative therapeutics need to be considered. New research explores the biochemical basis of virulence inhibition by mucus glycans against the fungal pathogen Candida albicans.

    • Jehoshua Sharma
    • Rebecca S. Shapiro
    News & Views
    Nature Chemical Biology
    Volume: 18, P: 684-686

  • Interactions between proteins and non-proteinaceous biopolymers are essential for life; however, many methods used to characterize these interactions lack precision and display significant biases. Now, a genetically encoded method employing sulfur(vi) fluoride exchange (SuFEx)-based chemical crosslinking has been developed for capturing and analysing protein–RNA and protein–carbohydrate interactions in vivo.

    • Christopher P. Watkins
    • Ryan A. Flynn
    News & Views
    Nature Chemistry
    Volume: 15, P: 5-6

  • Software solutions pGlyco3 and StrucGP both aim to better assign the glycan part of a glycopeptide beyond simple glycosyl composition, but they differ in their strategies, their requirement for a glycan library and their applicability to O-glycopeptides.

    • Kay-Hooi Khoo
    News & Views
    Nature Methods
    Volume: 18, P: 1457-1458

  • In situ labeling with azido sugars enables in vivo immunomodulation of dendritic cells.

    • Madhura Mukhopadhyay
    Research Highlights
    Nature Methods
    Volume: 17, P: 651

  • The biological functions of glycan motifs such as the Lewis blood antigens are often defined by their precise multivalent presentation on complex glycoconjugates, making synthesis particularly challenging. Access to a number of positionally defined Lewis motifs on natural polysaccharide scaffolds has now been achieved using bacterial glycosyltransferases.

    • Kun Huang
    • Sabine L Flitsch
    News & Views
    Nature Catalysis
    Volume: 2, P: 479-480

  • A suite of new enzymes reveals more on how Nature breaks down plant-based polysaccharides and how these enzymes might be harnessed in the utilization of plant-based biomass.

    • Paul H. Walton
    News & Views
    Nature Chemical Biology
    Volume: 16, P: 815-816

  • A comprehensive genetic screen reveals new cellular trafficking factors and linker-dependent requirements for antibody–drug conjugate (ADC) cytotoxicity. These new insights may guide the design of optimized ADCs.

    • Heather A. Van Epps
    • Peter D. Senter
    News & Views
    Nature Chemical Biology
    Volume: 15, P: 934-935

  • A new study demonstrates that the receptor-binding domain of the SARS-CoV-2 spike protein binds to sialylated glycans, especially glycolipids, to facilitate viral entry, an insight that identifies new potential targets for SARS-CoV-2 interventions.

    • Ryuta Uraki
    • Yoshihiro Kawaoka
    News & Views
    Nature Chemical Biology
    Volume: 18, P: 6-7

  • Extracellular peptidoglycan-linked polysaccharide modifications mediate cell morphology, division, and autolysis in some Gram-positive bacterial pathogens. A new study shows that the degree and location of a specific modification controls peptidoglycan hydrolysis and placement of the axis of cell division.

    • Malcolm E. Winkler
    News & Views
    Nature Chemical Biology
    Volume: 17, P: 841-843