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Showing 1–50 of 327 results

  • In this Tools of the Trade article, Khalid Ibrahim (Radenovic and Lashuel labs) describes a tool for the artificial intelligence (AI)-driven detection of cellular aggregates that bypasses the need for fluorescent labelling.

    • Khalid A. Ibrahim
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 25, P: 337

  • Cytoplasmic mislocalization of TDP-43 in neurodegenerative disease affects mRNA maturation and protein levels of stathmin-2, leading to a reduction in axon diameter and tearing of outer myelin layers and thereby disrupting neuronal function.

    • Lisa Heinke
    Research Highlights
    Nature Reviews Neuroscience
    Volume: 25, P: 78

  • A single gene in astrocytes can constrain repetitive behaviours, indicating that these cells are regulators of behavioural disruption in conditions such as Huntington’s disease and obsessive–compulsive disorder.

    • Anna Kruyer
    News & Views
    Nature
    Volume: 627, P: 279-280

  • Active neurons can stimulate the clearance of their own metabolic waste by driving changes to ion gradients in the surrounding fluid and by promoting the pulsation of nearby blood vessels.

    • Lauren Hablitz
    • Maiken Nedergaard
    News & Views
    Nature
    Volume: 627, P: 44-45

  • Using a data-driven proteomics strategy from a prospective community-based cohort with long-term follow-up, this study reports that plasma levels of glial fibrillary acidic protein (GFAP) can predict the risk of dementia, even 15 years before disease diagnosis. Our findings have important implications for early screening and interventions for dementia.

    News & Views
    Nature Aging
    Volume: 4, P: 173-174

  • The monoclonal antibody donanemab, which clears amyloid plaques in the brain, slowed clinical progression of early symptomatic Alzheimer’s disease.

    • Karen O’Leary
    Research Highlights
    Nature Medicine

  • Gut microbiome changes are present in both preclinical Alzheimer disease and prodromal Parkinson disease, new research indicates.

    • Lisa Kiani
    Research Highlights
    Nature Reviews Neurology
    Volume: 19, P: 458

  • A one-time gene-editing therapy restored motor function and prolonged lifespan in mice, spurring further research to refine and optimize the approach for future clinical use.

    • Karen O’Leary
    Research Highlights
    Nature Medicine

  • A new study provides the strongest support yet for abnormal α-synuclein as a diagnostic biomarker that shows up even in the prodromal phase — with immediate implications for trial design and therapeutic development.

    • Karen O’Leary
    Research Highlights
    Nature Medicine

    • Yiyun Song
    Research Highlights
    Nature Chemical Biology
    Volume: 19, P: 536

  • A new study in Science reports the mechanism through which TDP-43 enables correct processing of STMN2 mRNA, and proposes strategies to restore neuronal Stathmin-2 synthesis in TDP-43 proteinopathies.

    • Linda Koch
    Research Highlights
    Nature Reviews Genetics
    Volume: 24, P: 346

  • Certain viruses — many of which have vaccines available — are linked to a significantly increased risk of neurodegenerative disease in the years following infection.

    • Karen O’Leary
    Research Highlights
    Nature Medicine

  • In a mouse model of tauopathy, neurodegeneration is dependent on the gut microbiota and is affected by apolipoprotein E isoform expression.

    • Darran Yates
    Research Highlights
    Nature Reviews Neuroscience
    Volume: 24, P: 133

  • An effective treatment for the most common form of dementia has so far eluded researchers, but it’s not for want of trying.

    • Richard Hodson
    Comments & Opinion
    Nature
    Volume: 559, P: S1

    • Laurie A. Dempsey
    Research Highlights
    Nature Immunology
    Volume: 23, P: 2

  • A new study shows that in its native state, α-synuclein predominantly exists as an α-helical tetramer rather than an unfolded monomer.

    • Darran Yates
    Research Highlights
    Nature Reviews Neuroscience
    Volume: 12, P: 550

  • The blockbuster medications that reduce body weight also reduce inflammation in organs such as the brain, raising hopes that they can treat Parkinson's and Alzheimer's diseases.

    • Mariana Lenharo
    News
    Nature
    Volume: 626, P: 246

    • Yiyun Song
    Research Highlights
    Nature Chemical Biology
    Volume: 18, P: 434

  • A study in mice links a metabolite of the gut microbiota to age-related microglia death.

    • Ursula Hofer
    Research Highlights
    Nature Reviews Microbiology
    Volume: 20, P: 446

  • A rationally designed treatment for Creutzfeldt–Jakob disease — the first of its kind — appears to safely reach target levels in the brain, which provides justification for further clinical trials.

    • Karen O’Leary
    Research Highlights
    Nature Medicine

  • Despite gaps in our understanding of the biology that underlies this neurodegenerative condition, potential treatments are on the horizon.

    • Herb Brody
    Comments & Opinion
    Nature
    Volume: 557, P: S35

  • The characteristic brain pathology and motor symptoms of Parkinson's disease are well established. But the details of the disease's cause and course are much murkier.

    • Sarah Deweerdt
    Comments & Opinion
    Nature
    Volume: 538, P: S17

    • Sian Lewis
    Research Highlights
    Nature Reviews Neuroscience
    Volume: 20, P: 252

  • Compounds that tether toxic proteins with polyglutamine expansions to autophagosomes promote their autophagic clearance and might, in principle, be suitable for the treatment of associated neurodegenerative diseases.

    • Kim Baumann
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 20, P: 718-719

  • Two studies identify a mechanism linking TDP-43 pathology with genetic variants associated with increased risk of neurodegenerative disorders.

    • Natasha Bray
    Research Highlights
    Nature Reviews Neuroscience
    Volume: 23, P: 255