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Showing 1–43 of 43 results

    • Grant Miura
    Research Highlights
    Nature Chemical Biology
    Volume: 19, P: 391

    • Yiyun Song
    Research Highlights
    Nature Chemical Biology
    Volume: 16, P: 481

  • Loop-seq is a high-throughput sequencing assay that measures DNA looping and can help explain how DNA bendability contributes to nucleosome organization.

    • Lei Tang
    Research Highlights
    Nature Methods
    Volume: 18, P: 121

  • A chemical approach for precisely mapping nucleosomes genome-wide provides novel insights into the regulation of transcription and splicing.

    • Eytan Zlotorynski
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 3

  • DNA replication regulates nucleosome dynamics at the promoter of a negative element of the circadian clock, thereby providing regulatory feedback into circadian rhythms.

    • Paulina Strzyz
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 469

    • Stéphane Larochelle
    Research Highlights
    Nature Structural & Molecular Biology
    Volume: 20, P: 1145

  • DNA damage-induced histone degradation results in decreased nucleosome occupancy, which promotes homologous recombination by enhancing the dynamicity of chromatin.

    • Paulina Strzyz
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 139

  • The chromatin remodelling complex NuRD fine-tunes gene expression by modulating nucleosome density at gene regulatory elements.

    • Anne Mirabella
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 19, P: 545

  • Cellular engineering that allows budding yeast to survive with the four core human histones opens the door to exploring the function of histone variants and their modifications.

    • Nicole Rusk
    Research Highlights
    Nature Methods
    Volume: 15, P: 96-97

  • Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 11, P: 462

  • Pioneer transcription factors access gene regulatory sites embedded within chromatin. They drive gene expression programs vital for cell fate decisions and cellular reprogramming, but how they engage nucleosomal sites at the molecular level is unclear. New results show that they engage histones and collaborate to overcome the nucleosome barrier.

    • Magdalena Murawska
    • Andreas G. Ladurner
    • Carla E. Margulies
    News & Views
    Nature Structural & Molecular Biology
    Volume: 30, P: 1050-1053

  • Substrate–inhibitor conjugation facilitates structural determination of the KDM2A/B-nucleosome complexes, which provides mechanistic insights into the nucleosomal H3K36 demethylation by KDM2A/B and reveals a paralog-specific nucleosome acidic patch recognition mechanism mediated by the N terminus of KDM2A but not KDM2B.

    • Huasong Ai
    • Lei Liu
    News & Views
    Nature Chemical Biology
    Volume: 19, P: 542-543

  • DiMeLo-seq leverages immunotethered DNA methyltransferases with long-read sequencing to map the locations of chromatin proteins in their natural context.

    • Kami Ahmad
    News & Views
    Nature Methods
    Volume: 19, P: 651-652

  • High-throughput biochemical and biological analyses of disease-associated histone mutations reveal key residues in globular cores that affect chromatin remodeling, nucleosome stability, and stem cell pluripotency.

    • Kanishk Jain
    • Brian D. Strahl
    News & Views
    Nature Chemical Biology
    Volume: 17, P: 370-371

  • Two new studies in Nature provide insight into the role of nucleosomes in gene regulation. One describes the genome-wide organization of nucleosomes and the other details how transcription factor binding to DNA is affected by the presence of nucleosomes.

    • Dorothy Clyde
    Research Highlights
    Nature Reviews Genetics
    Volume: 19, P: 738-739

  • The development of new strategies to deplete maternal histone proteins in vivo and in vitro has led to the discovery of unexpected roles of histones in forming a functional nuclear envelope.

    • Peter J Skene
    • Steven Henikoff
    News & Views
    Nature Structural & Molecular Biology
    Volume: 21, P: 651-652

  • Two studies in Molecular Cell report fine-scale structural profiles of mammalian genomes using Micro-C, indicating that fine chromosomal structure is regulated by diverse transcription-related features.

    • Darren J. Burgess
    Research Highlights
    Nature Reviews Genetics
    Volume: 21, P: 337

  • Cells replicate half of their genome as short fragments that are put together later on. The way in which this process is linked to the formation of DNA–protein complexes called nucleosomes is now becoming clearer. See Article p.434

    • Alysia Vandenberg
    • Geneviève Almouzni
    News & Views
    Nature
    Volume: 483, P: 412-413

  • A new study shows that alteration of poly(dA:dT) tracts in promoters offers a broadly applicable genetic mechanism for predictably tuning gene expression with high resolution. By systematically manipulating these tracts in a controlled yeast system, the authors demonstrate quantitative mechanistic relationships linking regulatory DNA sequences, nucleosome occupancy, transcription factor binding and gene expression.

    • Timothy Palpant
    • Jason Lieb
    News & Views
    Nature Genetics
    Volume: 44, P: 735-736

  • According to the 'classical' view, histone modifications are established in an identical fashion on both copies of each of the four core histones, resulting in 'symmetrically' modified nucleosomes. Now, a new study challenges this notion by demonstrating that asymmetric histone modifications exist on individual mononucleosomes in native chromatin and that symmetric and asymmetric modifications signal different biological outcomes, suggesting a radically expanded histone code.

    • Barth van Rossum
    • Wolfgang Fischle
    • Philipp Selenko
    News & Views
    Nature Structural & Molecular Biology
    Volume: 19, P: 1064-1066

  • MCM2, a component of the replicative helicase, can bind histones H3–H4 in both tetrameric and dimeric form, depending on the presence of the histone chaperone ASF1. A structural analysis of the complexes now sheds light on key domains in the MCM2 protein that prove important for cell proliferation.

    • Camille Clément
    • Geneviève Almouzni
    News & Views
    Nature Structural & Molecular Biology
    Volume: 22, P: 587-589

  • William Earnshaw describes the events that led to the discovery and cloning of the first kinetochore proteins 30 years ago using autoimmune sera from patients with scleroderma-spectrum disease. He also discusses our current appreciation of the complexity of this remarkable structure.

    • William C. Earnshaw
    Comments & Opinion
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 443-449