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Showing 1–50 of 458 results

  • We show that the mitochondrial fission proteins MiD49 and MiD51 are activated by fatty acyl-coenzyme A (FA-CoA). FA-CoA binds in a previously identified pocket located within MiDs, inducing their oligomerization and ability to activate the dynamin DRP1, ultimately promoting mitochondrial fission. Activated MiDs synergize with mitochondrial fission factor (MFF) in stimulating DRP1 activity, leading us to hypothesize that MiDs act upstream of MFF during mitochondrial fission.

    News & Views
    Nature Cell Biology
    P: 1-2

  • Cellular and organismal aging have been consistently associated with mitochondrial dysfunction and inflammation. Accumulating evidence indicates that aging-related inflammatory responses are mechanistically linked to compromised mitochondrial integrity coupled with mtDNA-driven CGAS activation, a process that is tonically inhibited by mitophagy.

    • Emma Guilbaud
    • Kristopher A. Sarosiek
    • Lorenzo Galluzzi
    Comments & OpinionOpen Access
    Nature Communications
    Volume: 15, P: 1-3

  • High-fat diet (HFD) causes mitochondrial dysfunction in white adipocytes. A study in Nature Metabolism identifies the small GTPase RalA as a culprit in mice. Upon HFD, RalA activates the fission protein Drp1 to cause mitochondrial fragmentation and dysfunction, linking mitochondrial fuel utilization in white adipocytes to systemic lipid metabolism.

    • Ludovica Zambello
    • Luca Scorrano
    News & Views
    Nature Metabolism
    Volume: 6, P: 198-199

  • AMPK directly phosphorylates the mitochondrial protein SYNJ2BP to facilitate its interaction with the RNA-binding protein SYNJ2a, which transports Pink1 mRNA into neurites. AMPK inhibition downstream of insulin signalling untethers Pink1 mRNA from neuronal mitochondria and favours PINK1-dependent mitophagy in neurons. ApoE4-induced insulin receptor internalization reverses the process by stabilizing Pink1 mRNA binding to neuronal mitochondria.

    News & Views
    Nature Metabolism
    Volume: 6, P: 392-393

  • In this issue of Nature Metabolism, it is shown that the abundance of Caenorhabditis elegans branched-chain aminotransferase-1 (BCAT-1) — which catalyses the first step of branched-chain amino acid (BCAA) catabolism — declines sharply in aged wild-type nematodes but not in slowly ageing mutants, and that stimulating BCAA catabolism extends reproductive longevity.

    • Leah E. Jamerson
    • Patrick C. Bradshaw
    News & Views
    Nature Metabolism
    P: 1-3

  • The endoplasmic reticulum (ER) controls the synthesis of lipids and proteins and Ca2+ homeostasis, as well as contacting other organelles and the plasma membrane. A study now looks at a process by which this compartment is remodelled in axons during neurogenesis: the lysosomal clearance of ER subdomains, driven by FAM134 and CCPG1 proteins.

    • Maurizio Molinari
    News & Views
    Nature Cell Biology
    Volume: 26, P: 316-317

  • Basal mitophagy can occur independently of the kinase PINK1 in mammalian organisms, calling for further studies to elucidate the mechanisms of mitophagyin vivo.

    • Kim Baumann
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 19, P: 76

  • Two studies report a novel membrane contact site between mitochondria and lysosome-like vacuoles in yeast, and reveal a physical and metabolic link between mitochondria and the endocytic compartment.

    • Andrea Du Toit
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 15, P: 561

    • Rachel David
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 14, P: 688

  • High-throughput and ultrasensitive mass spectrometry–based approaches are gaining ground in subcellular compositional analysis.

    • Arunima Singh
    Comments & Opinion
    Nature Methods
    Volume: 19, P: 28

  • Ernst and Renne highlight two papers, one that discovered and another that structurally defined the ER–mitochondria encounter structure (ERMES) that facilitates the exchange of lipids between the ER and mitochondria.

    • Mike F. Renne
    • Robert Ernst
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 25, P: 161

  • Myocardial infarction causes endoplasmic reticulum (ER) stress, thereby triggering the release of a set of poorly defined growth factors. A study shows that the growth factor CRELD2 is secreted in response to ER stress and is required for preserving heart function after myocardial infarction in mice.

    News & Views
    Nature Cardiovascular Research
    Volume: 3, P: 108-109

  • Three independent studies in human cell lines reveal new functions of membrane contact sites between the endoplasmic reticulum (ER) and mitochondria and between the ER and peroxisomes.

    • Paulina Strzyz
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 139

  • Navdeep Chandel highlights a study published in 1996 that — by showing that mitochondria can release cytochromecto initiate apoptosis — changed his view of the role of mitochondria in physiology.

    • Navdeep S. Chandel
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 19, P: 76

  • ER contact with mitochondria positions mitochondrial constriction and fission.

    • Alison Schuldt
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 627

  • The mitochondrial outer membrane is a source of starvation-induced autophagosomes.

    • Katharine H. Wrighton
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 11, P: 464

  • Our knowledge of autophagy has taken several 'quantum leaps' since the term was coined by Christian de Duve.

    • Patrice Codogno
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 15, P: 153

    • Grant Miura
    Research Highlights
    Nature Chemical Biology
    Volume: 18, P: 679

  • Despite a growing understanding of the immunostimulatory properties of mitochondrial DNA (mtDNA), little is known about how and why mtDNA escapes its mitochondrial confines. A study now describes an endosomal trafficking pathway that facilitates mtDNA egress and provides an additional mechanism of mtDNA release in vitro.

    • Kate McArthur
    • Benjamin T. Kile
    News & Views
    Nature Cell Biology
    Volume: 26, P: 177-178

  • Extracellular vesicles carry proteins and lipids between cells. In a giant step forward for the field, a 2007 study published in Nature Cell Biology showed that secreted vesicles contain genetic material that is active within acceptor cells, reviving interest in extracellular vesicle-based communication in plant and animal biology.

    • Graça Raposo
    • Philip D. Stahl
    News & Views
    Nature Cell Biology
    Volume: 26, P: 22-23

  • Han et al. employed an in vivo imaging workflow that coupled positron emission tomography imaging to micro-computed tomography and 3D serial block-face electron microscopy to produce a detailed structural and functional map of mitochondrial networks in lung cancer.

    • Anna Dart
    Research Highlights
    Nature Reviews Cancer
    Volume: 23, P: 273

    • Caitlin Deane
    Research Highlights
    Nature Chemical Biology
    Volume: 16, P: 1037

  • The prevailing notion that mitochondrial diseases arise from ATP deficiency is challenged by recent evidence that oxidative phosphorylation defects trigger maladaptive stress responses consuming excess energy. We argue that this chronic state of hypermetabolism imposes energetic constraints, thus causing mitochondrial disease pathophysiology, calling for careful translational studies from organelle to organism.

    • Alexander J. Sercel
    • Gabriel Sturm
    • Martin Picard
    Comments & Opinion
    Nature Metabolism
    Volume: 6, P: 192-195

    • Caitlin Deane
    Research Highlights
    Nature Chemical Biology
    Volume: 16, P: 225

  • Electron transfer flavoprotein dehydrogenase (ETFDH), respiratory chain complex III and the coenzyme Q10 synthesis regulator COQ2 interact as a protein complex that is disrupted in ETFDH deficiency, with potential implications for disease therapy.

    • Jerry Vockley
    News & Views
    Nature Metabolism
    Volume: 6, P: 196-197

    • Laurie A. Dempsey
    Research Highlights
    Nature Immunology
    Volume: 23, P: 2

  • In this Tools of the Trade article, Nouf Laqtom (at the Abu-Remaileh lab) describes the LysoIP system used to tag and isolate lysosomes for multi-omic approaches and to determine their composition under physiological and pathological states.

    • Nouf N. Laqtom
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 24, P: 773

  • In this Tools of the Trade article, Benjamin Jackson (at the Finley lab) describes the use of genetic co-essentiality analysis to interrogate the assembly of metabolic networks, fuelling discovery of new aspects of metabolism.

    • Benjamin T. Jackson
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 24, P: 378

  • Tan and Finkel report a novel phosphoinositide-initiated membrane tethering and lipid transport (PITT) pathway that is crucial for lysosome membrane repair.

    • Lisa Heinke
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 23, P: 697

    • Grant Miura
    Research Highlights
    Nature Chemical Biology
    Volume: 18, P: 1037