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Showing 1–50 of 77 results

    • Grant Miura
    Research Highlights
    Nature Chemical Biology
    Volume: 18, P: 793

    • Grant Miura
    Research Highlights
    Nature Chemical Biology
    Volume: 18, P: 1291

  • Ventricular arrhythmias are associated with aging and are a leading cause of sudden cardiac death. A new study shows that hyperactivation of p38γ/δ MAPKs is a key driver of stress-induced ventricular arrhythmias via increased phosphorylation of ryanodine receptor 2 at Ser2367 and impaired localization of potassium voltage-gated channel Kv4.3.

    • Joshua A. Keefe
    • Xander H. T. Wehrens
    News & Views
    Nature Cardiovascular Research
    Volume: 2, P: 1104-1106

  • A set of 80 (mostly synaptic) proteins show hyperphosphorylation in sleep-deprived mice and genetically ‘sleepy’ mice, suggesting that increased phosphorylation of such proteins may be associated with sleep need.

    • Natasha Bray
    Research Highlights
    Nature Reviews Neuroscience
    Volume: 19, P: 444

    • Grant Miura
    Research Highlights
    Nature Chemical Biology
    Volume: 13, P: 1057

    • Alison Farrell
    Research Highlights
    Nature Chemical Biology
    Volume: 13, P: 1

  • Philip Cohen highlights how two studies from the laboratory of Zhijian Chen, published in 2000 and 2001, started a new era in the study of signal transduction pathways and the roles of ubiquitin chains.

    • Philip Cohen
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 19, P: 212

  • A study now shows that PP2A–B56 achieves specificity by binding to a LxxIxE motif.

    • Katharine H. Wrighton
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 17, P: 534-535

  • A new study shows that phosphorylation regulates the folding, and thus biological function, of the intrinsically disordered protein 4E-BP2.

    • Katharine H. Wrighton
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 66

    • Joshua M. Finkelstein
    Research Highlights
    Nature Chemical Biology
    Volume: 9, P: 755

    • Paulina Strzyz
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 703

  • Chlaymydomonas reinhardtiisenses the absolute length of its flagella and converts this length to a phosphorylation signal.

    • Joanna E. Huddleston
    Research Highlights
    Nature Reviews Microbiology
    Volume: 9, P: 397

    • Grant Miura
    Research Highlights
    Nature Chemical Biology
    Volume: 9, P: 755

    • Grant Miura
    Research Highlights
    Nature Chemical Biology
    Volume: 11, P: 632

    • Andrea Du Toit
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 15, P: 367

    • Grant Miura
    Research Highlights
    Nature Chemical Biology
    Volume: 11, P: 549

    • Laurie A Dempsey
    Research Highlights
    Nature Immunology
    Volume: 15, P: 14

  • Stress-induced phosphorylation of CDT1 by JNK1 prevents HBO1 recruitment to inhibit replication.

    • Joanna E. Huddleston
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 623

  • RND GTPases are regulated by 14-3-3 binding to a hybrid phosphorylation prenyl motif in RND.

    • Alison Schuldt
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 14, P: 326-327

  • The TGFβ-induced protein TMEPAI negatively regulates TGFβ signalling.

    • Katharine H. Wrighton
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 11, P: 163

  • Phosphorylation of ATF2 leads to heritable disruption of heterochromatin.

    • Joanna E. Huddleston
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 462

  • The Hippo signalling pathway regulates spindle orientation and asymmetric cell division

    • Paulina Strzyz
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 703

  • A new report shows that phosphorylation of eukaryotic translation initiation factor 2α regulates the conversion ofPlasmodiumspp. salivary gland sporozoites into liver-stage sporozoites.

    • Sheilagh Molloy
    Research Highlights
    Nature Reviews Microbiology
    Volume: 8, P: 611

  • Protein nanopores can detect post-translational modifications in proteins.

    • Tal Nawy
    Research Highlights
    Nature Methods
    Volume: 11, P: 226-227

  • CDKs regulate autophagy by phosphorylating and inactivating VPS34.

    • Katharine H. Wrighton
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 11, P: 464

  • Phosphorylation is a key regulator of oligodendrocyte transcription factor 2 activity in CNS development.

    • Darran Yates
    Research Highlights
    Nature Reviews Neuroscience
    Volume: 12, P: 248

  • PRMT5 methylates RAF proteins to decrease their stability and reduce ERK activation.

    • Katharine H. Wrighton
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 689

  • Under steady-state conditions, the E3 ubiquitin ligase Parkin is localized to the cytosol in an autoinhibited state. Two recent studies describe the mechanism of Parkin activation by phosphorylation via structural rearrangement of the Ubl and RING2 domains, explaining how the RING2 domain is released from the core of Parkin to allow for ubiquitination of its substrates.

    • François Le Guerroué
    • Richard J. Youle
    News & Views
    Nature Structural & Molecular Biology
    Volume: 25, P: 644-646

  • In tumours, cancer cells can overcome energy stress via differential regulation of non-canonical ‘moonlighting’ functions of metabolic enzymes. A study now shows that the metabolic phosphatase fructose-1,6-bisphosphatase 1 (FBP1) can act as a nuclear protein phosphatase and reveals how this process is inhibited in cancer cells.

    • Scott A. Gerber
    • Arminja N. Kettenbach
    News & Views
    Nature Cell Biology
    Volume: 24, P: 1568-1570

  • Activation signals from GPCRs, the largest receptor family, are transmitted to heterotrimeric G proteins and arrestins, and can be differentially modulated by GPCR phosphorylation. In a recent article, available data, including multiple arrestin structures, are analyzed to decipher common and state-specific conformational changes in arrestins and how these depend on patterns of receptor phosphorylation.

    • Christopher J. Draper-Joyce
    • Arthur Christopoulos
    News & Views
    Nature Structural & Molecular Biology
    Volume: 25, P: 437-439

  • The activation of dendritic cells by Toll-like receptors leads to a rapid enhancement in glycolysis. Glucose is metabolized to pyruvate and from there to citrate in the mitochondria, which leads ultimately to membrane biosynthesis in the endoplasmic reticulum and Golgi to support the activation of dendritic cells.

    • Luke A J O'Neill
    News & Views
    Nature Immunology
    Volume: 15, P: 314-315

  • In recent years, the molecular view of clear cell renal cell carcinoma (ccRCC) has been based primarily on gene transcription data with limited information on protein features. A new study led by the Clinical Proteomic Tumor Analysis Consortium now offers a comprehensive view of the ccRCC proteome.

    • Chad J. Creighton
    News & Views
    Nature Reviews Nephrology
    Volume: 16, P: 133-134