Alterations in DNA and histone modifications are known to occur during development and in disease. The changes that occur during TGF-β–triggered epithelial-to-mesenchymal transition are now examined on a global scale. DNA methylation remained relatively stable, but major changes in histone modifications, dependent on the histone demethylase Lsd1, were observed, particularly in large, organized heterochromatic Lys9-methylated regions.
- Oliver G McDonald
- Hao Wu
- Andrew P Feinberg