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Showing 1–3 of 3 results
Advanced filters: Author: " Somlata" Clear advanced filters

  • The phagocytosis of bacteria and other cells by trophozoites is an important process required for nutrition and pathogenesis. The authors identify a kinase, EhC2PK, that binds to the calcium-binding protein, EhCaBP1, and find that both proteins are involved in phagocytosis by the parasiteEntamoeba histolytica.

    • Somlata
    • Sudha Bhattacharya
    • Alok Bhattacharya
    Research
    Nature Communications
    Volume: 2, P: 1-10

  • Entamoeba histolytica can kill host cells by trogocytosis, while it ingests dead cells by phagocytosis. Here, Somlata et al. show that EhAGCK1, an AGC family kinase, is specifically involved in trogocytosis, shedding light on the molecular differences between trogocytosis and phagocytosis.

    • Somlata
    • Kumiko Nakada-Tsukui
    • Tomoyoshi Nozaki
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Entamoeba histolytica, the causative agent of fatal diarrhoeal disease in children in the developing world, is shown here to kill human cells by biting off and ingesting pieces of cells, in a process reminiscent of the trogocytosis seen between immune cells; ingestion of bites is required for killing and this mechanism is used both in tissue culture and during invasion of intestinal explants.

    • Katherine S. Ralston
    • Michael D. Solga
    • William A. Petri Jr
    Research
    Nature
    Volume: 508, P: 526-530