Research into the effects of lower-extremity muscle weakness on osteoarthritis onset and progression has increased over the past decade, owing to its potential for modification using exercise training interventions. Similarly, afferent sensory dysfunction has also been suggested as an important yet modifiable risk factor for OA progression. In this Review, the authors provide an overview of these risk factors, and discuss the effectiveness of preventive or therapeutic neuromuscular and exercise training interventions.
- Ewa M. Roos
- Walter Herzog
- Kim L. Bennell