The symptomatic pre-arthritis phase of rheumatoid arthritis (RA) is hypothesized to be part of a 'window of opportunity' for preventive treatment. This Review discusses the methodological considerations when designing and interpreting preventive trials, and translating findings into clinical practice.
- Hanna W. van Steenbergen
- José A. Pereira da Silva
- Annette H. M. van der Helm-van Mil