The authors report that the mRNA for myo-inositol monophosphatase-1, an enzyme that regulates the inositol cycle and the main target of lithium in neurons, is localized to axons. They identify a novel NGF-responsive localization element within the 3′ UTR that directs this targeting and local translation.
- Catia Andreassi
- Carola Zimmermann
- Antonella Riccio