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Showing 1–38 of 38 results
Advanced filters: Author: "A. Brown" Clear advanced filters

  • A spatiotemporal quantification of Fusarium head blight (FHB) mycotoxins in European food and feed wheat highlights the omnipresence of deoxynivalenol and increasing detection of other FHB mycotoxins. These potential health and economic costs emphasize the need to monitor FHB mycotoxin outbreaks and to understand what is driving this change, so that we can develop appropriate mitigation strategies.

    • Louise E. Johns
    • Daniel P. Bebber
    • Neil A. Brown
    ResearchOpen Access
    Nature Food
    Volume: 3, P: 1014-1019

  • A perceptive history documents the many remarkable people who envisioned, built and launched the Hubble Space Telescope, explains Robert A. Brown.

    • Robert A. Brown
    Books & Arts
    Nature
    Volume: 454, P: 694-695

  • The pathophysiology of heart failure is complex, but mitochondrial dysfunction is an emerging therapeutic target to improve cardiac function. In this Consensus Statement, insights into the mechanisms of mitochondrial dysfunction in heart failure are presented, along with an overview of emerging treatments with the potential to improve the function of the failing heart by targeting mitochondria.

    • David A. Brown
    • Justin B. Perry
    • Mihai Gheorghiade
    ReviewsOpen Access
    Nature Reviews Cardiology
    Volume: 14, P: 238-250

  • Research into the genetics of immune and inflammatory disease has experienced major recent advances owing to the availability of a custom single-nucleotide polymorphism (SNP) genotyping array — the Immunochip — developed specifically to investigate these disorders. In this Analysis, the authors assess findings from studies that have used this platform, and explore the shared and phenotype-specific genetic associations among several immune-mediated diseases.

    • Miles Parkes
    • Adrian Cortes
    • Matthew A. Brown
    Research
    Nature Reviews Genetics
    Volume: 14, P: 661-673

    • Alastair Brown
    Research Highlights
    Nature Climate Change
    Volume: 9, P: 257

    • Alastair Brown
    Research Highlights
    Nature Climate Change
    Volume: 8, P: 764

  • The proinflammatory cytokine IL-17 is known to be an important factor in the pathogenesis of autoimmune joint diseases such as rheumatoid arthritis and spondyloarthritis, and therapies targeting this cytokine have shown promise. Although type 17 T helper cells are generally considered to be the main source of IL-17 in these diseases, the range of cell types that secrete this cytokine continues to expand; in particular, mast cells are receiving increased attention. Herein, the authors discuss the potential contribution of IL-17-secreting mast cells to inflammatory joint disease.

    • Tony J. Kenna
    • Matthew A. Brown
    Reviews
    Nature Reviews Rheumatology
    Volume: 9, P: 375-379

  • Genome sequencing reveals similarities between rice grown by Maroon communities in Suriname and landraces from the Guinea Highlands of West Africa.

    • Terence A. Brown
    News & Views
    Nature Plants
    Volume: 2, P: 1-2

  • Elderly patients with end-stage renal disease (ESRD) have a number of unique features that impact on the management of this condition. In this Review, Brown and Johansson highlight factors that need to be considered when treating elderly patients with ESRD. The authors also discuss the advantages and limitations of dialysis modalities in elderly patients with ESRD as well as the option of conservative care.

    • Edwina A. Brown
    • Lina Johansson
    Reviews
    Nature Reviews Nephrology
    Volume: 7, P: 591-598

    • Alastair Brown
    Research Highlights
    Nature Climate Change
    Volume: 9, P: 352

    • Alastair Brown
    Research Highlights
    Nature Climate Change
    Volume: 8, P: 854

    • Alastair Brown
    Research Highlights
    Nature Climate Change
    Volume: 8, P: 359

    • Alastair Brown
    Research Highlights
    Nature Climate Change
    Volume: 8, P: 457

    • Alastair Brown
    Research Highlights
    Nature Climate Change
    Volume: 8, P: 559

    • Alastair Brown
    Research Highlights
    Nature Climate Change
    Volume: 7, P: 853

    • Alastair Brown
    Research Highlights
    Nature Climate Change
    Volume: 8, P: 662

    • Alastair Brown
    Research Highlights
    Nature Climate Change
    Volume: 8, P: 1033

  • The sequencing of ancient DNA is generating dramatic results. The sequence from a bone fragment has revealed the existence of an unknown type of extinct human ancestor that lived in Asia 40,000 years ago.

    • Terence A. Brown
    News & Views
    Nature
    Volume: 464, P: 838-839

  • Can peer review be improved by withholding information from referees? There is some evidence to suggest it might be, but the jury is still out, reports Alastair Brown.

    • Alastair Brown
    Comments & Opinion
    Nature Nanotechnology
    Volume: 9, P: 871-872

  • Omissions of qualified women scientists from major meeting programs continue to occur despite a surge in articles indicating persistent gender-discriminatory practices in hiring and promotion, and calls for gender balance in conference organizing committees.

    • Robyn S Klein
    • Rhonda Voskuhl
    • Anne H Cross
    Comments & Opinion
    Nature Immunology
    Volume: 18, P: 475-478

  • Ongoing research continues to show only moderate accuracy of all methods of measuring proteinuria in pregnant women with hypertension. We need to change traditional thinking so that emphasis on the detection or quantitation of proteinuria is not greater than emphasis on other clinical or laboratory features in the diagnosis or management of pre-eclampsia.

    • Mark A. Brown
    News & Views
    Nature Reviews Nephrology
    Volume: 8, P: 563-565

  • What makes the human body a good growth medium for bacterial pathogens? In this Review, Brown, Palmer and Whiteley outline how the host growth environment affects disease and discuss the potential for targeting host metabolic pathways for therapeutic development.

    • Stacie A. Brown
    • Kelli L. Palmer
    • Marvin Whiteley
    Reviews
    Nature Reviews Microbiology
    Volume: 6, P: 657-666

  • In this Review, the authors discuss the latest insights into the genetic associations and pathological mechanisms of ankylosing spondylitis, in particular HLA-B27-mediated pathology, antigen-presentation pathways and the role of type 3 immunity.

    • Vidya Ranganathan
    • Eric Gracey
    • Nigil Haroon
    Reviews
    Nature Reviews Rheumatology
    Volume: 13, P: 359-367

  • Strategies to reduce myocardial infarct size beyond early reperfusion have thus far yielded disappointing results in clinical trials. In this Review, Kloner and co-workers discuss several new approaches to preserve the reperfused myocardium, including those that target mitochondrial bioenergetics and autophagy.

    • Robert A. Kloner
    • David A. Brown
    • Jianru Shi
    Reviews
    Nature Reviews Cardiology
    Volume: 14, P: 679-693