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Showing 1–8 of 8 results
Advanced filters: Author: "A. Guskov" Clear advanced filters

  • Glutamate transporters are membrane transporters that clear the neurotransmitter L-glutamate from the synaptic cleft via a so-called elevator mechanism. Here the authors present five cryo-EM structures of the transporter homologue GltTk, which explain how substrate leakage is prevented.

    • Valentina Arkhipova
    • Albert Guskov
    • Dirk J. Slotboom
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • A cryo-EM structure of the human SLC1 transporter ASCT2 in the inward-facing conformation reveals the retrovirus-docking site and helps to elucidate the transport cycle. The transport domain is more solvent exposed than in most of the homolog structures.

    • Alisa A. Garaeva
    • Gert T. Oostergetel
    • Dirk J. Slotboom
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 515-521

  • The bacterial zinc transporter ZntB is important for maintaining zinc homeostasis and is mechanistically not well understood. Here, the authors present the cryo-EM structure of ZntB at 4.2 Å resolution, perform transport assays and propose a model for its Zn2+ transport mechanism.

    • Cornelius Gati
    • Artem Stetsenko
    • Albert Guskov
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-8

  • Prokaryotes use energy-coupling factor transporters to uptake required micronutrients and an unusual toppling mechanism has been proposed for their function. Here, the authors provide structural support for this mechanism, allowing direct visualization of the toppled state.

    • Lotteke J. Y. M. Swier
    • Albert Guskov
    • Dirk J. Slotboom
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • When bacteria enter the stationary growth phase, protein translation is suppressed via the dimerization of 70S ribosomes into inactive complexes. Here the authors provide a structural basis for how the dual domain hibernation promotion factor promotes ribosome dimerization and hibernation in bacteria.

    • Linda E. Franken
    • Gert T. Oostergetel
    • Albert Guskov
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11