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Showing 1–9 of 9 results
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  • Whole-genome sequencing of human malaria parasites has revealed genomic regions that are associated with resistance to artemisinin-based drugs. The findings may help to explain the origin and spread of this worrying trend.

    • A. Taylor Bright
    • Elizabeth A. Winzeler
    News & Views
    Nature
    Volume: 498, P: 446-447
  • Imaging biomarkers (IBs) are used extensively in drug development and cancer research, but important differences exist between IBs and biospecimen-derived biomarkers. A tailored 'roadmap' is required for the development of new IBs to be used either in clinical research or for decision-making in healthcare. In this Consensus statement, a group of experts assembled by CRUK and the EORTC present 14 key recommendations for accelerating the clinical translation of IBs.

    • James P. B. O'Connor
    • Eric O. Aboagye
    • John C. Waterton
    ReviewsOpen Access
    Nature Reviews Clinical Oncology
    Volume: 14, P: 169-186
  • The incidence of bladder cancer increases with age, and the management of high-grade disease in the elderly is challenging and costly. In this Review by Taylor and Kuchel, the authors evaluate the clinical and mechanistic interactions between bladder cancer and aging, and suggest directions and priorities for future research.

    • John A Taylor III
    • George A Kuchel
    Reviews
    Nature Reviews Urology
    Volume: 6, P: 135-144
  • A focus group of specialized urologic oncologists has reviewed guidelines and clinical evidence and discussed their experiences regarding the optimal use of BCG in the management of patients with NIMBC. Here, they provide a review of BCG therapy, clarify complex related topics and recommend best practice guidelines to improve BCG use and patient outcomes.

    • Ashish M. Kamat
    • Thomas W. Flaig
    • John A. Taylor III
    ReviewsOpen Access
    Nature Reviews Urology
    Volume: 12, P: 225-235