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Showing 1–13 of 13 results
Advanced filters: Author: "A. White" Clear advanced filters

  • MicroRNAs (MiRNAs) can act as oncogenes or tumor-suppressor genes and have differential expression in tumor progression and metastasis. MiRNAs are involved in a number of pathways that contribute to metastasis, including migration, invasion, cell proliferation, epithelial-to-mesenchymal transition, angiogenesis and apoptosis. This Review provides a summary of the existing data documenting these functions and describes the clinical utility of miRNAs as prognostic and predictive biomarkers and their potential therapeutic applications in advanced cancer.

    • Nicole M. A. White
    • Eman Fatoohi
    • George M. Yousef
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 8, P: 75-84

  • The Ras-family G-proteins RALA and RALB seem to be key offenders in the subversion of core biological systems driving oncogenic transformation. This up-to-date Review focuses on current developments within this field.

    • Brian O. Bodemann
    • Michael A. White
    Reviews
    Nature Reviews Cancer
    Volume: 8, P: 133-140

  • Centromeres, specialized regions on chromosomes, are essential for accurate chromosome segregation during cell division. In fission yeast, the RNA interference machinery has a pivotal function in the assembly of centromeric heterochromatin, which mediates sister centromere cohesion. Studies in vertebrate cells now suggest that many aspects of this process are conserved.

    • Sharon A. White
    • Robin C. Allshire
    News & Views
    Nature Cell Biology
    Volume: 6, P: 696-697

  • Orienting cancer drug discovery to the patient requires relating the genetic features of tumors to acquired gene and pathway dependencies and identifying small-molecule therapeutics that target them.

    • Stuart L Schreiber
    • Alykhan F Shamji
    • Bruce A Posner
    Comments & Opinion
    Nature Biotechnology
    Volume: 28, P: 904-906

  • Dietary plant polysaccharides are a major energy source for the anaerobic microbiota that inhabit the mammalian large intestine and rumen. Flint and colleagues discuss polysaccharide utilization by gut anaerobes, focusing on two examples, the use of insoluble structural polysaccharides byRuminococcus flavefaciens and the use of starch by Bacteroides thetaiotaomicron.

    • Harry J. Flint
    • Edward A. Bayer
    • Bryan A. White
    Reviews
    Nature Reviews Microbiology
    Volume: 6, P: 121-131

    • Richard H. Gomer
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 2, P: 48-55

  • The protein kinase C (PKC) family of highly related protein kinases are implicated in several diseases and have been a major focus of drug discovery efforts. However, no single drug specifically targeting a PKC isozyme has yet received approval. Here, Mochly-Rosen and colleagues review the efforts, challenges and opportunities in developing PKC modulators.

    • Daria Mochly-Rosen
    • Kanad Das
    • Kevin V. Grimes
    Reviews
    Nature Reviews Drug Discovery
    Volume: 11, P: 937-957

  • Jake Jones et al. show that changes in the metabolism of individual full-thickness skin wounds can be continuously measured in vivo using non-invasive autofluorescence imaging. This study presents endogenous optical biomarkers of chronic wounds, which offer promise in diagnosing impaired wound healing.

    • Jake D. Jones
    • Hallie E. Ramser
    • Kyle P. Quinn
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-8