Systemic lupus erythematosus (SLE) is a complex, autoimmune disorder that can have debilitating effects on various organs, including the kidneys. Here, Mohan and Putterman discuss the genetic candidates associated with SLE and lupus nephritis, and highlight possible molecular mechanisms that might contribute to disease pathology. Given the highly variable clinical presentation of SLE, the authors propose that greater understanding of the molecular basis of SLE and lupus nephritis is required to facilitate the generation of specific tailored therapies in the future.
- Chandra Mohan
- Chaim Putterman
