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Showing 1–4 of 4 results
Advanced filters: Author: "Alain Puisieux" Clear advanced filters

  • Claudin-low tumors are a rare aggressive subtype of breast cancers. In this study, the authors use a multiomics approach to demonstrate that these tumors are heterogeneous and comprise three main subgroups that emerge from different evolutionary processes.

    • Roxane M. Pommier
    • Amélien Sanlaville
    • Alain Puisieux
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • During malignant transformation, the ability of mammary epithelial cells to cope with oncogene-induced DNA damage and avoid chromosomal instability is determined by stemness-related expression of the canonical epithelial-to-mesenchymal transition transcription factor ZEB1 and its target MSRB3, a methionine sulfoxide reductase involved in antioxidant defense.

    • Anne-Pierre Morel
    • Christophe Ginestier
    • Alain Puisieux
    Research
    Nature Medicine
    Volume: 23, P: 568-578

  • Puisieux et al. discuss endothelial to mesenchymal transition (EMT)-inducing transcription factors in tumorigenesis. They explore how EMT contributes not only to tumour progression through its roles in invasion and metastasis, but also to malignant transformation and early tumour development by impinging on tumour suppressive pathways and cell differentiation states.

    • Alain Puisieux
    • Thomas Brabletz
    • Julie Caramel
    Reviews
    Nature Cell Biology
    Volume: 16, P: 488-494

  • In this review the authors argue that the inhibition of cell death is an important characteristic of metastatic cancer cells. Will this view identify new treatments for metastatic disease?

    • Patrick Mehlen
    • Alain Puisieux
    Reviews
    Nature Reviews Cancer
    Volume: 6, P: 449-458