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Showing 1–3 of 3 results
Advanced filters: Author: "Alan D D'Andrea" Clear advanced filters

  • To cope with the life-threatening crisis of a DNA interstrand cross-link (ICL), human cells must invoke the Fanconi anemia (FA) DNA repair pathway. The FA pathway is a multistep repair process, requiring multiple nucleolytic incisions and translesion DNA synthesis. Recent work from four laboratories has identified a novel FA-associated nuclease, FAN1, that binds directly to monoubiquitinated FANCD2, resolving a decade-long puzzle regarding the function of this FANCD2 modification.

    • Min Huang
    • Alan D D'Andrea
    News & Views
    Nature Structural & Molecular Biology
    Volume: 17, P: 926-928

  • Proteins of the Fanconi anaemia pathway are master regulators of genomic integrity through their interactions with other DNA repair pathways to repair interstrand crosslinks, stabilize replication forks and regulate cytokinesis.

    • Raphael Ceccaldi
    • Prabha Sarangi
    • Alan D. D'Andrea
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 17, P: 337-349

  • Recent studies have highlighted the crucial role of ubiquitin and ubiquitin-like modifications in the regulation of translesion DNA synthesis and various DNA-repair processes such as homologous recombination, nucleotide-excision repair and base-excision repair.

    • Tony T. Huang
    • Alan D. D'Andrea
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 7, P: 323-334