Epigenetic, or nonheritable, mechanisms that regulate gene expression are potentially reversible. In this short article, authors involved in identification of the chemokine RANTES (CCL5) outline the complex pathways that control its expression and thereby influence movement of immune cells, with a focus on T lymphocytes. Rational design of agents based on this knowledge could have a beneficial impact on various forms of nephritis and nephropathy, transplant rejection and acute renal failure.
- Alan M Krensky
- Yong-Tae Ahn
