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Showing 1–2 of 2 results
Advanced filters: Author: "Alberto Inga" Clear advanced filters

  • Several lncRNAs are regulated by TGF-β. Here the authors report that an intergenic lncRNA —EPR— is a component of the TGF-β signaling pathway and controls epithelial cell proliferation by altering transcription and mRNA decay of Cdkn1a. EPR overexpression restrains tumor growth of orthotopically transplanted mice.

    • Martina Rossi
    • Gabriele Bucci
    • Roberto Gherzi
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Target response element sequences are a crucial part of the p53 network. This Review describes how functional response elements can be defined and discusses the implications of non-canonical p53 response elements, which greatly expand the universe of p53-regulated genes, on the part that p53 plays as a tumour suppressor.

    • Daniel Menendez
    • Alberto Inga
    • Michael A. Resnick
    Reviews
    Nature Reviews Cancer
    Volume: 9, P: 724-737