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Showing 1–9 of 9 results
Advanced filters: Author: "Alex Sigal" Clear advanced filters

  • There is limited data on immune factors contributing to SARS-CoV-2 viral clearance in people living with HIV. Here, the authors show that re-emergence of the neutralizing antibody response may be key to clearing persistent SARS-CoV-2 infection in ART-mediated recovery from immunosuppression in advanced HIV disease.

    • Farina Karim
    • Catherine Riou
    • Alex Sigal
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • The Omicron BA.2.86 subvariant differs from previous variants by over 30 spike mutations. Here, the authors report that BA.2.86 likely evolved in Southern Africa and that its immune escape is not larger than recently circulating SARS-CoV-2 strains. Neither its replication nor its pathogenicity are enhanced in vitro.

    • Khadija Khan
    • Gila Lustig
    • Alex Sigal
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-9

  • Emerging SARS-CoV-2 Omicron sub-lineages BA.4 and BA.5 raise concerns about potential immune evasion. Here, Khan et al. show that both BA.4 and BA.5 are able to escape immune response induced by prior BA.1 infection, but that this effect is less pronounced in vaccinated individuals.

    • Khadija Khan
    • Farina Karim
    • Alex Sigal
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-7

  • Cross-neutralization assays of early variants and the 501Y.V2 variant of SARS-CoV-2 show that plasma from individuals infected with 501Y.V2 effectively neutralizes all variants, indicating that a vaccine that targets 501Y.V2 may also be effective against other SARS-CoV-2 variants.

    • Sandile Cele
    • Inbal Gazy
    • Alex Sigal
    Research
    Nature
    Volume: 593, P: 142-146

  • A study quantifying the neutralization of severe acute respiratory syndrome coronavirus 2 variants in individuals infected with Omicron/BA.1 shows that vaccinated individuals previously infected with Omicron have enhanced protection against reinfection with current variants, \including Omicron/BA.2, while Omicron/BA.1 infected unvaccinated individuals have limited protection.

    • Khadija Khan
    • Farina Karim
    • Alex Sigal
    ResearchOpen Access
    Nature
    Volume: 607, P: 356-359

  • Plasma from individuals vaccinated with BNT162b2 exhibits 22-fold less neutralization capacity against Omicron (B.1.1.529) than against an ancestral SARS-CoV-2 strain but residual neutralization is maintained in those with high levels of neutralization of ancestral virus.

    • Sandile Cele
    • Laurelle Jackson
    • Alex Sigal
    ResearchOpen Access
    Nature
    Volume: 602, P: 654-656

  • The Omicron variant of SARS-CoV-2 has been reported to cause milder disease in adults but lead to increased hospital admissions in children. How can we compare disease severity in Omicron and Delta infections, and how should differences be interpreted?

    • Alex Sigal
    • Ron Milo
    • Waasila Jassat
    Comments & Opinion
    Nature Reviews Immunology
    Volume: 22, P: 267-269