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Showing 1–5 of 5 results
Advanced filters: Author: "Alexander Rudensky" Clear advanced filters

  • An approach to inhibit the immune-suppressive function of regulatory T cells is demonstrated in a model of graft-versus-host disease.

    • Catherine Konopacki
    • George Plitas
    • Alexander Rudensky
    News & Views
    Nature Biotechnology
    Volume: 33, P: 718-719

  • This Review describes the recent advances in our understanding of the role of TGFβ (transforming growth factor-β) signalling in the regulation of T-cell differentiation in the thymus and periphery, with particular emphasis on TGFβ-mediated control of self-reactive T cells.

    • Yuri P Rubtsov
    • Alexander Y Rudensky
    Reviews
    Nature Reviews Immunology
    Volume: 7, P: 443-453

  • Surprisingly, and somewhat counter-intuitively, partial T-cell immunodeficiencies are commonly associated with hyper-immune dysregulation. Here, the authors review the genetic basis of such immunodeficiencies and draw on mouse models to provide a potential explanation for the coexistence of immunodeficiency and autoimmunity.

    • Adrian Liston
    • Anselm Enders
    • Owen M. Siggs
    Reviews
    Nature Reviews Immunology
    Volume: 8, P: 545-558

  • How are regulatory T (TReg) cells selected in the thymus? What is the role of T cell receptor specificity in the generation of self antigen-specific TReg cells? What is the involvement of thymic antigen-presenting cells in TReg cell differentiation and how is FOXP3 expression induced in developing thymocytes? Here, the authors summarize the latest findings in the field of TRegcells to provide answers to these long-standing questions.

    • Chyi-Song Hsieh
    • Hyang-Mi Lee
    • Chan-Wang J. Lio
    Reviews
    Nature Reviews Immunology
    Volume: 12, P: 157-167