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Showing 1–4 of 4 results
Advanced filters: Author: "Alexander Varshavsky" Clear advanced filters

  • The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. The N-end rule pathway, ubiquitin-dependent in eukaryotes, is also present in prokaryotes, which lack the ubiquitin system. An illuminating new study presents the crystal structure of a bacterial N-end rule recognition component in complex with a peptide containing a cognate degradation signal.

    • Alexander Varshavsky
    News & Views
    Nature Structural & Molecular Biology
    Volume: 15, P: 1238-1240

  • The N-end rule defines the protein-destabilizing activity of a given amino-terminal residue following its post-translational modification. The N-end rule pathway is emerging as a major cellular proteolytic system, and recent studies provide insights into its components, substrates and functions, as well as the structural basis of substrate recognition.

    • Shashikanth M. Sriram
    • Bo Yeon Kim
    • Yong Tae Kwon
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 735-747