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Showing 1–4 of 4 results
Advanced filters: Author: "Ali Shilatifard" Clear advanced filters

  • This article discusses the possible function of the super elongation complex (SEC) and the DOT1 H3K79 methyltransferase complex (DotCom) in leukaemia that is induced by translocation of mixed lineage leukaemia (MLL).

    • Man Mohan
    • Chengqi Lin
    • Ali Shilatifard
    Reviews
    Nature Reviews Cancer
    Volume: 10, P: 721-728

  • The super elongation complex (SEC) consists of the RNA polymerase II (Pol II) elongation factors eleven-nineteen Lys-rich leukaemia (ELL) proteins, positive transcription elongation factor b (P-TEFb) and several frequent mixed lineage leukaemia (MLL) translocation partners. The SEC controls transcription elongation in the presence or absence of promoter-proximal paused Pol II, and its gene target specificity depends on protein components forming distinct SEC complexes.

    • Zhuojuan Luo
    • Chengqi Lin
    • Ali Shilatifard
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 543-547

  • The WD40 protein WDR5 is a core subunit of the human MLL and SET1 (hCOMPASS) histone H3 Lys4 (H3K4) methyltransferase complexes. Although initial studies suggested that WDR5 interacts with methylated H3K4 to catalyze Lys4 trimethylation, recent work has revealed that it binds an arginine-bearing motif in MLL1, promoting complex assembly and activity. These findings suggest that WDR5 functions as a peptidyl arginine–recognition factor that facilitates the assembly of hCOMPASS and other chromatin-modifying complexes.

    • Raymond C Trievel
    • Ali Shilatifard
    Comments & Opinion
    Nature Structural & Molecular Biology
    Volume: 16, P: 678-680

  • Large-scale, next-generation sequencing collaborations have identified drivers and vulnerabilities of urothelial carcinoma. In this Review, the authors discuss the mutational landscape of urothelial carcinoma, including specific mutations in pathways and driver genes and describe how the next generation of therapies will be based on patient-specific targetable mutations observed in individual tumours.

    • Alexander P. Glaser
    • Damiano Fantini
    • Joshua J. Meeks
    Reviews
    Nature Reviews Urology
    Volume: 14, P: 215-229