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Showing 1–8 of 8 results
Advanced filters: Author: "Alison Simmons" Clear advanced filters

  • Mutations in NOD2—a bacterial sensor in dendritic cells—and mutations in genes related to autophagosome function have been linked to Crohn's disease. Alison Simmons and her colleagues link these susceptibility genes in a single functional pathway. They show that triggering of NOD2 induces autophagy, resulting in increased bacterial antigen presentation on the surface of the dendritic cell. They also show that this process goes awry in dendritic cells expressing the susceptibility variants from individuals with Crohn's disease.

    • Rachel Cooney
    • John Baker
    • Alison Simmons
    Research
    Nature Medicine
    Volume: 16, P: 90-97

  • Variations in several genes can increase an individual's susceptibility to complex disorders. But what tips the balance to cause the full-blown disease? For Crohn's disease, viruses could provide part of the answer.

    • Alison Simmons
    News & Views
    Nature
    Volume: 466, P: 699-700

  • Multimodal single-cell profiling reveals heterogeneity of colonic CD8+ T cells in patients with ulcerative colitis, including expansion of a chronically activated IL-26-expressing subpopulation with innate-like features.

    • Daniele Corridoni
    • Agne Antanaviciute
    • Alison Simmons
    Research
    Nature Medicine
    Volume: 26, P: 1480-1490

  • Profiling of single epithelial cells in healthy and inflamed colons identifies specialized cellular subpopulations, including a type of goblet cell that secretes the antibacterial protein WFDC2, which preserves the integrity of the epithelial barrier layer.

    • Kaushal Parikh
    • Agne Antanaviciute
    • Alison Simmons
    Research
    Nature
    Volume: 567, P: 49-55

  • Meta-analysis of single-cell RNA sequencing datasets identifies core fibroblasts present in all organs that may give rise to more specialized organ-specific subtypes.

    • Agne Antanaviciute
    • David Fawkner-Corbett
    • Alison Simmons
    News & Views
    Nature Immunology
    Volume: 22, P: 944-946

  • Salmonella employ a range of strategies to counter host defences during infection. Here, Aulicino et al. use single-cell RNA-sequencing to examine the effects of invasive and non-invasive strains of Salmonella, revealing discrete and divergent immune evasion strategies in infected and bystander dendritic cells.

    • Anna Aulicino
    • Kevin C. Rue-Albrecht
    • Alison Simmons
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • Aulicino, Antanaviciute et al investigate the transcriptional response to invasive Salmonella strains in dendritic cells (DCs). They show that S. Typhi mount a response against nitrosative stress pathways and propose a role of iron uptake and transport in preventing infection, which the pathogen can bypass. In parallel, they find that invasive Salmonella employs several mechanisms targeting more classic aspects of immunity to impair DC function.

    • Anna Aulicino
    • Agne Antanaviciute
    • Alison Simmons
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-17