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Showing 1–4 of 4 results
Advanced filters: Author: "Alpha S. Yap" Clear advanced filters
  • Research on the cadherin–junctional actin interaction has focused on how the two physically interact. However, the actin cytoskeleton is dynamic, regulated by a network of proteins, so a broader perspective that takes this into account may provide new insights on cadherin cell–cell contacts and on the role of cadherins in disease.

    • Aparna Ratheesh
    • Alpha S. Yap
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 673-679
  • Transporting epithelia commonly consist of tubes that mediate between the body and its environment. Lumen formation is closely linked to epithelial morphogenesis, but an open question is how luminal symmetry is broken to generate tubes rather than hollow cysts. A report about the biomechanics of intercellular contacts might now provide some answers.

    • Kenneth Wee
    • Alpha S. Yap
    News & Views
    Nature Cell Biology
    Volume: 18, P: 255-257
  • α-catenin exists as part of the cadherin–catenin adhesion complex as well as in a cytoplasmic pool. However, which of these pools is responsible for its biological impact remains controversial. A structure-function analysis in Drosophila melanogaster illuminates how the molecular properties of α-catenin translate into functional outcomes in an intact organism.

    • Siew-Ping Han
    • Alpha S. Yap
    News & Views
    Nature Cell Biology
    Volume: 15, P: 238-239