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Showing 1–4 of 4 results
Advanced filters: Author: "Andrea Ballabio" Clear advanced filters

  • The mechanisms by which cells detect and fight foreign organisms is crucial for the host defense against infection. The sensing of cytosolic DNA is pivotal in this process, is kept in check by the exonuclease Trex1 and has been linked to lysosomal biogenesis via the transcription factor TFEB in an interferon-independent manner.

    • Anna Katharina Simon
    • Andrea Ballabio
    News & Views
    Nature Immunology
    Volume: 14, P: 10-12

  • Two studies find that an intracellular quality-control mechanism called autophagy is regulated by nuclear receptor proteins that govern the expression of autophagy genes. See Letters p.108 & p.112

    • Carmine Settembre
    • Andrea Ballabio
    News & Views
    Nature
    Volume: 516, P: 40-41

  • As well as degrading and recycling cellular waste, lysosomes are involved in secretion, plasma membrane repair, signalling and energy metabolism. The identification of transcription factor EB (TFEB) as a central regulator of lysosomal biogenesis and autophagy provides insight into how lysosomes adapt to environmental cues, and targeting TFEB may be a promising therapeutic strategy for modulating lysosomal function in disease.

    • Carmine Settembre
    • Alessandro Fraldi
    • Andrea Ballabio
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 14, P: 283-296