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Showing 1–4 of 4 results
Advanced filters: Author: "Andreas Geier" Clear advanced filters

  • This Case Study describes a 24-year-old white male with Crohn's disease that was in remission who presented with cholestasis and hyperbilirubinemia. The patient had normal alanine aminotrasferase and γ-globulin levels, and the results of serological tests for an infectious cause of hepatopathia were negative. The patient was diagnosed with autoimmune hepatitis–primary sclerosing cholangitis overlap syndrome on the background of primary sclerosing cholangitis.

    • Leif E Sander
    • Alexander Koch
    • Andreas Geier
    Reviews
    Nature Clinical Practice Gastroenterology & Hepatology
    Volume: 4, P: 635-640

  • Cholangiocarcinomas are a heterogeneous group of bile duct cancers and the second most common primary liver tumour worldwide. In this Consensus statement, the newly formed European Network for the Study of Cholangiocarcinoma (ENS-CCA) detail the classification, pathophysiology and underlying mechanisms, and current therapies for cholangiocarcinoma, as well as future perspectives.

    • Jesus M. Banales
    • Vincenzo Cardinale
    • Domenico Alvaro
    ReviewsOpen Access
    Nature Reviews Gastroenterology & Hepatology
    Volume: 13, P: 261-280

  • Over the past decade, inflammation-induced alterations at the hepatocellular, bile ductular and ductal level have been linked to different clinical presentations of cholestasis in sepsis. In this Review, the authors give a comprehensive overview of the molecular and cellular mechanisms that underlie sepsis-associated cholestasis and the potential clinical and therapeutic implications that these mechanisms have for critically ill patients.

    • Andreas Geier
    • Peter Fickert
    • Michael Trauner
    Reviews
    Nature Clinical Practice Gastroenterology & Hepatology
    Volume: 3, P: 574-585