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Showing 1–7 of 7 results
Advanced filters: Author: "Andreas Trumpp" Clear advanced filters

  • Haematopoietic stem cells (HSCs) can reside as dormant cells in endosteal niches in the bone marrow, where they are resistant to certain types of chemotherapy. In this article, the authors suggest that by first awakening dormant HSCs to become actively self-renewing cells, this resistance to chemotherapy could be overcome.

    • Andreas Trumpp
    • Marieke Essers
    • Anne Wilson
    Reviews
    Nature Reviews Immunology
    Volume: 10, P: 201-209

  • All cells of the immune system are derived from precursor cells in the bone marrow known as haematopoietic stem cells (HSCs). This Review describes recent advances in our understanding of the specialized bone-marrow niches that regulate HSC differentiation and self-renewal.

    • Anne Wilson
    • Andreas Trumpp
    Reviews
    Nature Reviews Immunology
    Volume: 6, P: 93-106

  • The interaction between hematopoietic stem cells and their niche is critical for the lifelong maintenance of the blood system. New research shows that crosstalk between stromal components of the niche mediates secretion of the chemokine CXCL12.

    • Michael D Milsom
    • Andreas Trumpp
    News & Views
    Nature Immunology
    Volume: 12, P: 377-379

  • Cancer cells have a raised cellular metabolism, including increased protein biosynthesis. Three new studies now show that the oncoprotein Myc, known to drive cell division, also enhances ribosomal RNA synthesis by RNA polymerase I in addition to controlling RNA polymerase II- and III-regulated gene transcription. This suggests that Myc promotes the generation of crucial components of a functional ribosome.

    • Thordur Oskarsson
    • Andreas Trumpp
    News & Views
    Nature Cell Biology
    Volume: 7, P: 215-217

  • Cancer stem cells often represent a minor, highly self-renewing population within the tumor mass and are thought to be the only cells required for both initiation and maintenance of disease. The biology of cancer stem cells, the mechanisms of therapy resistance, and potential future therapeutic interventions in the clinical setting are discussed.

    • Andreas Trumpp
    • Otmar D Wiestler
    Reviews
    Nature Clinical Practice Oncology
    Volume: 5, P: 337-347