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Showing 1–6 of 6 results
Advanced filters: Author: "Andrew Dillin" Clear advanced filters

  • Proteome maintenance was thought to be controlled in a cell-autonomous manner. However, recent findings suggest that proteostasis can be systemically regulated. Protein-folding defects systemically activate proteostasis mechanisms through signalling pathways that coordinate stress responses among tissues, and this may also coordinate ageing rates between tissues.

    • Rebecca C. Taylor
    • Kristen M. Berendzen
    • Andrew Dillin
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 15, P: 211-217

  • Aging is a major risk factor for the development of human neurodegenerative diseases. Here, Cohen and Dillin discuss the roles of insulin/IGF1 signalling in toxic protein aggregation and the links between this pathway and the emergence of late-onset neurodegenerative disease.

    • Ehud Cohen
    • Andrew Dillin
    Reviews
    Nature Reviews Neuroscience
    Volume: 9, P: 759-767

  • Natural variations in the rate of protein translation in cellular organelles called mitochondria have been found to correlate with lifespan, suggesting a unified mechanism for the effects of metabolic alterations on longevity. See Article p.451

    • Suzanne Wolff
    • Andrew Dillin
    News & Views
    Nature
    Volume: 497, P: 442-443

  • An investigation into cellular stress responses reveals how cell compartments called mitochondria use information about the surrounding metabolites and microorganisms to protect themselves from damage. See Letter p.406

    • Suzanne Wolff
    • Andrew Dillin
    News & Views
    Nature
    Volume: 508, P: 328-329

  • The multiprotein nuclear pore complexes (NPCs) that mediate nucleocytoplasmic transport are universal and essential for cell viability. However, cell type-specific expression of particular NPC components and specialized NPC functions now point towards a previously unrecognized heterogeneity in these ancient pores.

    • Marcela Raices
    • Maximiliano A. D'Angelo
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 687-699