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Showing 1–6 of 6 results
Advanced filters: Author: "Angus W Thomson" Clear advanced filters

  • Angus Thomson and colleagues describe the consequences of mammalian target of rapamycin (mTOR) inhibition by rapamycin on dendritic cells, effector T cells and regulatory T cells. These effects make mTOR inhibition a promising immunosuppressive, but tolerance-promoting, therapeutic strategy.

    • Angus W. Thomson
    • Hēth R. Turnquist
    • Giorgio Raimondi
    Reviews
    Nature Reviews Immunology
    Volume: 9, P: 324-337

  • The mTOR pathway has a role in the development of renal disease, kidney transplant rejection and malignancies. Here, the authors discuss the mechanisms by which mTOR complexes drive the pathogenesis of these diseases as well as the therapeutic potential of mTOR inhibitors.

    • Daniel Fantus
    • Natasha M. Rogers
    • Angus W. Thomson
    Reviews
    Nature Reviews Nephrology
    Volume: 12, P: 587-609

  • Renal dendritic cells and macrophages are key factors in the initiation and propagation of renal disease and tissue regeneration. In this Review, the authors discuss the common and distinct characteristics of dendritic cells and macrophages as well as current understanding of the renal-specific functions of these important phagocytic, antigen-presenting cell types in potentiating or mitigating intrinsic kidney disease.

    • Natasha M. Rogers
    • David A. Ferenbach
    • Jeremy Hughes
    Reviews
    Nature Reviews Nephrology
    Volume: 10, P: 625-643

  • The mechanisms by which local antigen-presenting cells, such as myeloid and plasmacytoid dendritic cells, liver sinusoidal endothelial cells, Kupffer cells and hepatocytes, mediate tolerance to antigens metabolized in the liver are described here. These insights into hepatic tolerance may be harnessed in the clinic for the treatment of various diseases.

    • Angus W. Thomson
    • Percy A. Knolle
    Reviews
    Nature Reviews Immunology
    Volume: 10, P: 753-766

  • Tolerogenic dendritic cells (DCs) have potential as therapeutic tools for preventing transplant rejection. This Review describes what constitutes a tolerogenic DC, how tolerogenic DCs can be induced, the mechanisms by which they mediate tolerance and the future challenges facing DC-based immunotherapy.

    • Adrian E. Morelli
    • Angus W. Thomson
    Reviews
    Nature Reviews Immunology
    Volume: 7, P: 610-621