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Showing 1–4 of 4 results
Advanced filters: Author: "Anna Akhmanova" Clear advanced filters

  • The kinesin-4 motor protein Kif7 regulates Hedgehog signalling at cilia in mammals by controlling the activity of Gli transcription factors. Kif7 is now found to inhibit microtubule growth to restrict and coordinate the length of axonemal microtubules at the ciliary tip. Such Kif7-mediated organization of the ciliary tip compartment regulates Gli activity and is proposed to be required for correct Hedgehog signalling.

    • Lotte B. Pedersen
    • Anna Akhmanova
    News & Views
    Nature Cell Biology
    Volume: 16, P: 623-625

  • How do cytoskeletal components interact to control cellular processes? At the growing microtubule plus ends, microtubule plus-end tracking proteins (+TIPs) regulate different aspects of cell architecture by controlling microtubule dynamics, microtubule interactions with cellular structures and signalling factors, and forces exerted on microtubule networks.

    • Anna Akhmanova
    • Michel O. Steinmetz
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 9, P: 309-322

  • Microtubule plus ends and minus ends accumulate specific sets of proteins that can regulate microtubule dynamics, connect microtubules to cellular structures and recruit signalling molecules that collectively control cellular behaviour. Our knowledge of the factors that associate with microtubule ends, and the mechanisms through which they do this, has strongly increased in recent years.

    • Anna Akhmanova
    • Michel O. Steinmetz
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 711-726