As molecular complexes that promote inflammation, inflammasomes have been implicated in several autoimmune and autoinflammatory disorders, including cryopyrin-associated periodic syndromes and microcrystal-induced pathologies. Here, the authors discuss the roles of inflammasomes in these conditions, as well as their potential involvement in other rheumatic diseases, and consider therapeutic approaches to inhibit inflammasome activity.
- Alexander So
- Annette Ives
- Nathalie Busso
